Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Inselspital Bern, Effingerstrasse 102, 3010, Bern, Switzerland.
Arch Gynecol Obstet. 2015 Jun;291(6):1213-20. doi: 10.1007/s00404-015-3618-0. Epub 2015 Jan 20.
In the past few years more and more research focused on psychosocial risk factors of cardiovascular disease, including depression. This review focuses on depression as a long-term risk factor for acute coronary syndrome in initially heart disease-free people.
The studies included (n = 15) comprised people without heart disease who were exposed to depression. The outcome was acute coronary syndrome (acute myocardial infarction, instable angina pectoris, sudden cardiac death). Only articles published in English between 2000 and 2013 were considered.
Most but not all studies found an association between depression and cardiac outcome. Possible explanations for the inconsistency of the findings are discussed.
Most likely there is an association between depression and acute coronary syndrome. However, it remains unclear whether depression acts as an independent risk factor for developing an acute coronary syndrome, or if depression promotes the development of an acute coronary syndrome by indirect means.
在过去的几年中，越来越多的研究关注心血管疾病的心理社会风险因素，包括抑郁症。本综述重点关注抑郁症作为最初无心脏病人群急性冠状动脉综合征的长期风险因素。
纳入的研究（n=15）包括患有抑郁症但无心脏病的人群。结局为急性冠状动脉综合征（急性心肌梗死、不稳定型心绞痛、心源性猝死）。仅考虑 2000 年至 2013 年间发表的英文文章。
大多数但并非所有研究都发现抑郁症与心脏结局之间存在关联。对研究结果不一致的可能解释进行了讨论。
很可能抑郁症与急性冠状动脉综合征之间存在关联。然而，目前尚不清楚抑郁症是否作为急性冠状动脉综合征发生的独立风险因素，或者抑郁症是否通过间接手段促进急性冠状动脉综合征的发展。
