巨噬细胞移动抑制因子（MIF）基因-173G>C多态性与多发性硬化症之间无关联。

Lack of association between MIF gene -173G>C polymorphism with multiple sclerosis.

作者信息

Cevik Betul, Yigit Serbulent, Karakus Nevin, Aksoy Durdane, Ates Omer, Kurt Semiha

机构信息

Gaziosmanpasa University Faculty of Medicine, Department of Neurology, Tokat, Turkey

Gaziosmanpasa University Faculty of Medicine, Department of Medical Biology, Tokat, Turkey.

出版信息

In Vivo. 2015 Jan-Feb;29(1):71-6.

PMID:25600533

Abstract

AIM

The aim of the present study was to investigate a possible association between the MIF -173G>C polymorphism and MS in Turkish patients.

MATERIALS AND METHODS

The study included 153 MS-patients and 210 controls. Genomic DNA was isolated and genotyped using PCR-RFLP assay for the MIF -173G>C promoter polymorphism (rs755622).

RESULTS

There was no statistically significant difference in allele and genotype frequencies between MS-patients and controls (p=0.227 and p=0.157, respectively). Accordingly, no association was observed when the patients were compared against controls in terms of GG versus GC+CC genotypes and GG+GC versus CC genotypes (p=0.324 and p=0.179, respectively). Also, there was no statistically significant association between MIF-173G>C polymorphism and clinical and demographic characteristics of MS-patients. Conlusion: The results of the present study suggest no relation between MS susceptibility and MIF gene - 173G>C polymorphism in the examined Turkish population.

摘要

目的

本研究旨在调查土耳其患者中MIF -173G>C多态性与多发性硬化症（MS）之间可能存在的关联。

材料与方法

该研究纳入了153例MS患者和210例对照。采用PCR-RFLP分析法对MIF -173G>C启动子多态性（rs755622）进行基因组DNA分离和基因分型。

结果

MS患者与对照之间的等位基因和基因型频率无统计学显著差异（分别为p = 0.227和p = 0.157）。因此，在GG与GC + CC基因型以及GG + GC与CC基因型方面，患者与对照相比未观察到关联（分别为p = 0.324和p = 0.179）。此外，MIF-173G>C多态性与MS患者的临床和人口统计学特征之间无统计学显著关联。结论：本研究结果表明，在所检测的土耳其人群中，MS易感性与MIF基因 - 173G>C多态性之间无关联。