• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人类红细胞有β-内啡肽的结合位点。

Human erythrocytes have binding sites for beta-endorphin.

作者信息

Simpkins C O, Chenet B P, Kang Y H, Mazorow D L, Millar D B, Hollis V W

出版信息

J Natl Med Assoc. 1989 Nov;81(11):1149-53.

PMID:2560064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2626097/
Abstract

Monoiodinated human beta-endorphin was found to bind specifically to human erythrocytes. Unlabeled beta-endorphin and beta-endorphin inhibited binding, but (-)naloxone, [D-Ala2, D-Leu5]-enkephalin, and leu- and met-enkephalin did not. Immunoelectron microscopy, using rabbit anti-beta-endorphin antibody, an antirabbit IgG secondary antibody, and complexed horseradish peroxidase, revealed that at low concentrations beta-endorphin binds to the cell surface. Electron spin resonance spectroscopy showed no effect of beta-endorphin on membrane fluidity. This receptor does not appear to conform to the characteristics of an opiate receptor.

摘要

单碘化人β-内啡肽被发现能特异性结合人红细胞。未标记的β-内啡肽和β-内啡肽可抑制结合，但（-）纳洛酮、[D-丙氨酸2，D-亮氨酸5]-脑啡肽以及亮氨酸脑啡肽和甲硫氨酸脑啡肽则无此作用。利用兔抗β-内啡肽抗体、抗兔IgG二抗以及复合辣根过氧化物酶进行免疫电子显微镜观察，结果显示在低浓度下β-内啡肽可结合于细胞表面。电子自旋共振光谱表明β-内啡肽对膜流动性无影响。该受体似乎不符合阿片受体的特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab8b/2626097/4e7fd2e32554/jnma00905-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab8b/2626097/4e7fd2e32554/jnma00905-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab8b/2626097/4e7fd2e32554/jnma00905-0058-a.jpg

相似文献

1
Human erythrocytes have binding sites for beta-endorphin.人类红细胞有β-内啡肽的结合位点。
J Natl Med Assoc. 1989 Nov;81(11):1149-53.
2
Binding of synthetic peptide TPLVTLFK to nonopioid beta-endorphin receptor on rat brain membranes.合成肽TPLVTLFK与大鼠脑膜上的非阿片类β-内啡肽受体的结合。
J Pept Sci. 2010 Jun;16(6):263-8. doi: 10.1002/psc.1231.
3
Comparison of [125I]beta-endorphin binding to rat brain and NG108-15 cells using a monoclonal antibody directed against the opioid receptor.使用针对阿片受体的单克隆抗体比较[125I]β-内啡肽与大鼠脑和NG108-15细胞的结合。
Mol Pharmacol. 1988 Feb;33(2):170-7.
4
Beta-endorphin: a highly selective endogenous opioid agonist for presynaptic mu opioid receptors.β-内啡肽：一种对突触前μ阿片受体具有高度选择性的内源性阿片激动剂。
J Pharmacol Exp Ther. 1991 Jul 1;258(1):237-42.
5
Beta-endorphin binding to naloxone-insensitive sites on a human mononuclear cell line (U937): effects of cations and guanosine triphosphate.β-内啡肽与人单核细胞系（U937）上对纳洛酮不敏感位点的结合：阳离子和三磷酸鸟苷的作用
Endocrinology. 1990 Jun;126(6):3006-15. doi: 10.1210/endo-126-6-3006.
6
Binding of naloxone to human T lymphocytes.纳洛酮与人T淋巴细胞的结合。
Biochem Pharmacol. 1987 Dec 1;36(23):4103-9. doi: 10.1016/0006-2952(87)90567-3.
7
Interaction of synthetic peptide octarphin (TPLVTLFK) with human blood lymphocytes.八肽肤轻松（TPLVTLFK）与人血淋巴细胞的相互作用。
J Pept Sci. 2013 Aug;19(8):499-503. doi: 10.1002/psc.2527. Epub 2013 Jun 23.
8
Binding of synthetic fragments of beta-endorphin to nonopioid beta-endorphin receptor.β-内啡肽合成片段与非阿片类β-内啡肽受体的结合
J Pept Sci. 2008 Oct;14(10):1121-8. doi: 10.1002/psc.1049.
9
Opioid receptor selectivity of beta-endorphin in vitro and in vivo: mu, delta and epsilon receptors.β-内啡肽在体外和体内对阿片受体的选择性：μ、δ和ε受体
J Pharmacol Exp Ther. 1988 Sep;246(3):1018-25.
10
Evidence that beta-endorphin binds to specific receptors in rat peripheral tissues and stimulates the adenylate cyclase-adenosine 3',5'-monophosphate system.有证据表明，β-内啡肽与大鼠外周组织中的特定受体结合，并刺激腺苷酸环化酶-3',5'-环磷酸腺苷系统。
Endocrinology. 1985 Oct;117(4):1389-96. doi: 10.1210/endo-117-4-1389.

引用本文的文献

1
Exploring the role of the endogenous opiate system in the pathogenesis of anemia in an opiate receptor knock-out model of Restless Legs Syndrome.在不宁腿综合征的阿片受体基因敲除模型中探究内源性阿片系统在贫血发病机制中的作用。
Med Hypotheses. 2022 Oct;167. doi: 10.1016/j.mehy.2022.110941. Epub 2022 Sep 5.

本文引用的文献

1
Specific non-opiate binding sites for human beta-endorphin on the terminal complex of human complement.人β-内啡肽在人补体终末复合物上的特异性非阿片样结合位点。
Nature. 1982 Apr 8;296(5857):572-4. doi: 10.1038/296572a0.
2
Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli.将甲酰甲硫氨酰亮氨酰苯丙氨酸纯化并鉴定为大肠杆菌产生的主要肽中性粒细胞趋化因子。
J Biol Chem. 1984 May 10;259(9):5430-9.
3
Human neutrophil migration is enhanced by beta-endorphin.
Life Sci. 1984 Jun 4;34(23):2251-5. doi: 10.1016/0024-3205(84)90213-3.
4
In vitro and in vivo effects of beta-endorphin and met-enkephalin on leukocyte locomotion.
Prog Brain Res. 1983;59:361-74. doi: 10.1016/s0079-6123(08)63882-0.
5
Enhancement of natural cytotoxicity by beta-endorphin.
J Immunol. 1983 Apr;130(4):1658-62.
6
Beta-endorphin modulates human immune activity via non-opiate receptor mechanisms.
Life Sci. 1982 Oct 11;31(15):1619-24. doi: 10.1016/0024-3205(82)90054-6.
7
beta-Endorphin enhances lymphocyte proliferative responses.β-内啡肽增强淋巴细胞增殖反应。
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4226-30. doi: 10.1073/pnas.79.13.4226.
8
Beta-endorphin modulates immune functions. A review.β-内啡肽调节免疫功能。综述。
Psychother Psychosom. 1984;42(1-4):195-204. doi: 10.1159/000287845.
9
The glomerular permeability determined by dextran clearance using Sephadex gel filtration.通过使用葡聚糖凝胶过滤法测定葡聚糖清除率来确定肾小球通透性。
Scand J Clin Lab Invest. 1968;21(1):77-82. doi: 10.3109/00365516809076979.
10
Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain.吗啡同系物左啡诺在小鼠脑亚细胞组分中的立体特异性和非特异性相互作用。
Proc Natl Acad Sci U S A. 1971 Aug;68(8):1742-7. doi: 10.1073/pnas.68.8.1742.