Akerman Simon, Goadsby Peter J
Headache Group, Department of Neurology, University of California, San Francisco, CA, USA.
Headache. 2015 Jan;55(1):197-203. doi: 10.1111/head.12471.
Trigeminal autonomic cephalalgias (TACs) are highly disabling primary headache disorders that involve severe unilateral head pain coupled with significant lateralized cranial autonomic features. Our understanding of these disorders and the development of novel and more effective treatments has been limited by the lack of a suitable animal model to explore their pathophysiology and screen prospective treatments.
This review details the development of a novel preclinical model that demonstrates activation of both the trigeminovascular system and parasympathetic projections, thought to be responsible for the severe head pain and autonomic symptoms.
This model demonstrates a unique response to TAC specific treatments and highlights the importance of the cranial parasympathetic pathway to the pathophysiology of TACs and as a potential locus of action for treatments. The development of this model opens up opportunities to understand the pathophysiology of these disorders further, the likely involvement of the hypothalamus, as well as providing a preclinical model with which to screen novel compounds.
三叉神经自主性头痛（TACs）是严重致残的原发性头痛疾病，其特征为单侧头部剧痛并伴有明显的同侧颅部自主神经症状。由于缺乏合适的动物模型来探究其病理生理学并筛选潜在治疗方法，我们对这些疾病的理解以及新型更有效治疗方法的开发一直受到限制。
本综述详细介绍了一种新型临床前模型的开发，该模型显示三叉神经血管系统和副交感神经投射均被激活，这被认为是导致严重头痛和自主神经症状的原因。
该模型展示了对TAC特异性治疗的独特反应，并突出了颅部副交感神经通路在TAC病理生理学中的重要性以及作为治疗潜在作用位点的重要性。该模型的开发为进一步理解这些疾病的病理生理学、下丘脑可能的参与情况提供了机会，同时也提供了一个用于筛选新型化合物的临床前模型。
