Department of Pediatrics, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan.
Infection. 2015 Jun;43(3):371-5. doi: 10.1007/s15010-015-0724-7. Epub 2015 Jan 20.
Chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired phagocyte killing of intracellular pathogens, is characterized by recurrent, life-threatening, bacterial and fungal infections. As a result of improvements in microbiologic culture and identification techniques, a number of unique filamentous fungi have been reported as significant pathogens in patients with CGD. We report a case of subcutaneous basidiomycete Phellinus mori infection in a patient with CGD. To the best of our knowledge, this is the first reported case of human infection by this fungus. The causative fungus was identified on the basis of its morphological characteristics and nucleotide sequence on the internal transcribed spacer region of the ribosomal RNA gene. This is the fifth case report of filamentous basidiomycetes infecting a patient with CGD; all of these cases have been caused by Phellinus species. We highlight the importance of recognizing filamentous basidiomycetes Phellinus species as possible agents of non-Aspergillus fungal infections in patients with CGD.
慢性肉芽肿病（CGD）是一种原发性免疫缺陷病，由于吞噬细胞无法杀死细胞内病原体而导致，其特征是反复发生、危及生命的细菌和真菌感染。由于微生物培养和鉴定技术的改进，许多独特的丝状真菌已被报道为 CGD 患者的重要病原体。我们报告了一例 CGD 患者的皮下担子菌桑黄感染病例。据我们所知，这是首例人类感染该真菌的病例。致病真菌是根据其形态特征和核糖体 RNA 基因内转录间隔区的核苷酸序列确定的。这是第五例丝状担子菌感染 CGD 患者的病例报告；所有这些病例均由桑黄属真菌引起。我们强调了认识丝状担子菌桑黄属真菌可能是 CGD 患者非曲霉真菌感染的重要性。
