Masugi F, Ogihara T, Sakaguchi K, Otsuka A, Tsuchiya Y, Morimoto S, Kumahara Y, Saeki S, Nishide M
Department of Geriatric Medicine, Osaka University Medical School, Japan.
Methods Find Exp Clin Pharmacol. 1989 Nov;11(11):707-10.
Plasma cortisol levels and other factors including thyroid hormone in patients with Alzheimer's type (n = 10), vascular type (n = 10) or mixed type (n = 10) senile dementia were compared with those in non-demented senile controls (n = 10). Plasma cortisol levels at 8:00 a.m. in Alzheimer's type dementia and mixed type dementia were 17.3 +/- 4.3 micrograms/dl (mean +/- SD) and 15.6 +/- 2.3 micrograms/dl, respectively. These values were significantly higher (p less than 0.005 and p less than 0.01) than those found in the control subjects (12.0 +/- 3.1 micrograms/dl). Plasma cortisol levels in vascular-type dementia (14.4 +/- 6.3 micrograms/dl) did not differ significantly from those in the controls. Plasma ACTH in senile dementia of the Alzheimer's type was lower, but not significant as compared with that in normal controls. In three subgroups of senile dementia and normal controls, plasma cortisol levels inversely correlated significantly with the degree of cognitive function. Plasma levels in TSH-thyroid system and blood pressure did not show any significant change in three types of senile dementia. These data suggest that senile dementia of the Alzheimer's type accompanies relatively and primarily high plasma cortisol levels and this may associate with cognitive dysfunction in Alzheimer's type senile dementia.
将阿尔茨海默型（n = 10）、血管型（n = 10）或混合型（n = 10）老年痴呆患者的血浆皮质醇水平及包括甲状腺激素在内的其他因素与非痴呆老年对照组（n = 10）进行比较。阿尔茨海默型痴呆和混合型痴呆患者上午8点的血浆皮质醇水平分别为17.3±4.3微克/分升（均值±标准差）和15.6±2.3微克/分升。这些值显著高于对照组（12.0±3.1微克/分升）（p＜0.005和p＜0.01）。血管型痴呆患者的血浆皮质醇水平（14.4±6.3微克/分升）与对照组无显著差异。阿尔茨海默型老年痴呆患者的血浆促肾上腺皮质激素较低，但与正常对照组相比无显著差异。在老年痴呆和正常对照组的三个亚组中，血浆皮质醇水平与认知功能程度呈显著负相关。三种类型的老年痴呆患者的促甲状腺激素 - 甲状腺系统血浆水平和血压均未显示任何显著变化。这些数据表明，阿尔茨海默型老年痴呆伴有相对较高且主要是较高的血浆皮质醇水平，这可能与阿尔茨海默型老年痴呆的认知功能障碍有关。
