Weidenfeld J, Aburia S, Lysy J, Shohami E
Department of Neurology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Prostaglandins Leukot Essent Fatty Acids. 1989 Dec;38(3):173-6. doi: 10.1016/0952-3278(89)90068-9.
In the present study we evaluated the role of endogenous glucocorticoids in the biosynthesis of prostaglandins (PG) in cortical brain tissue of the rat. Experiments were carried out under basal conditions and in response to insulin-induced hypoglycemia and 2-deoxyglucose (2-DG) induced-cytoglucopenia. In intact rats, following hypoglycemia and cytoglucopenia, the production of brain PG was decreased. These two stress stimuli also activated adrenocortical secretory responses, as manifested by an increase in circulating ACTH and corticosterone. Bilateral adrenalectomy did not modify the brain production of PG under basal conditions. In contrast, in adrenal-ectomized rats, the biosynthesis of brain cortical PG was markedly increased in response to insulin and 2-DG. These results suggest that adrenal hormones may be involved in the modulation of cortical PG production under stressful conditions.
在本研究中，我们评估了内源性糖皮质激素在大鼠大脑皮质组织中前列腺素（PG）生物合成中的作用。实验在基础条件下进行，并针对胰岛素诱导的低血糖和2-脱氧葡萄糖（2-DG）诱导的细胞葡萄糖减少做出反应。在完整的大鼠中，低血糖和细胞葡萄糖减少后，脑PG的产生减少。这两种应激刺激还激活了肾上腺皮质分泌反应，表现为循环促肾上腺皮质激素（ACTH）和皮质酮增加。双侧肾上腺切除术在基础条件下并未改变脑PG的产生。相反，在肾上腺切除的大鼠中，响应胰岛素和2-DG，大脑皮质PG的生物合成显著增加。这些结果表明，肾上腺激素可能参与应激条件下皮质PG产生的调节。
