Desforges C, Venault P, Dodd R H, Chapouthier G, Roubertoux P L
URA 1294, CNRS, UFR Biomédicale Paris V, France.
Pharmacol Biochem Behav. 1989 Dec;34(4):733-7. doi: 10.1016/0091-3057(89)90267-0.
The inbred mouse strains BALB/cBy (C) and C57BL/6By (B6) differed significantly in their susceptibility to seizures induced by the benzodiazepine inverse agonist methyl beta-carboline-3-carboxylate (beta-CCM). Following a 5 mg/kg injection of beta-CCM, 74% of C (n = 35) and 13% of B6 (n = 40) mice exhibited a convulsion. No sex difference was found. Analysis of the reciprocal F1s failed to show either maternal environmental and/or heterosomal effects. A genetic analysis of the strain difference in susceptibility to beta-CCM-induced seizures using recombinant inbred strains (RIS) was performed. The strain distribution for the RIS showed a two group partition. Statistical analysis showed that, although a one-segregating-unit model could not be rejected to explain the strain difference in beta-CCM-induced seizures, some of the evidence weakened the one-segregating-unit hypothesis.
近交系小鼠品系BALB/cBy（C）和C57BL/6By（B6）对苯二氮䓬反向激动剂β-咔啉-3-羧酸甲酯（β-CCM）诱导的癫痫发作的易感性存在显著差异。注射5mg/kg的β-CCM后，74%的C品系小鼠（n = 35）和13%的B6品系小鼠（n = 40）出现惊厥。未发现性别差异。对 reciprocal F1s的分析未显示母本环境和/或异染色体效应。使用重组近交系（RIS）对β-CCM诱导的癫痫发作易感性的品系差异进行了遗传分析。RIS的品系分布显示为两组划分。统计分析表明，虽然不能排除单分离单位模型来解释β-CCM诱导的癫痫发作的品系差异，但一些证据削弱了单分离单位假说。
