Dusek J, Siegelová J, Prikryl P, Kunovská V, Mayer P
Vnitr Lek. 1989 Nov;35(11):1079-86.
A group of patients with essential hypertension and healthy subjects from the same work place were investigated for a period of four weeks and were subjected, in addition to a basic clinical medical examination, to an ergometric examination ECHO cardiography, occlusion plethysmography, and concurrently serum levels of adrenaline (A), noradrenaline (NA), renin, cyclic adenosine monophosphate (cAMP) beta receptors before and after four weeks treatment with enalapril were assessed. The results are consistent with available data from the literature where administration of inhibitors of the angiotensin converting enzyme (ACE) caused a reduction of the peripheral vascular resistance and increased blood flow assessed by means of occlusion plethysmography. Similar results were recorded after captopril administration for a one year period, as reported by Agabiti-Rose (1). Statistically significant differences were detected between hypertonics given placebo and those given enalapril for four weeks, as regards blood flow at rest and peripheral vascular resistance at rest. There was also a significant difference when hypertonic and normotonic subjects were compared. The results are presented in tables and figures.
对一组原发性高血压患者和来自同一工作场所的健康受试者进行了为期四周的调查。除了进行基本的临床医学检查外，他们还接受了运动测试、超声心动图检查、体积描记法检查，并且在使用依那普利治疗四周前后，同时评估了血清肾上腺素（A）、去甲肾上腺素（NA）、肾素、环磷酸腺苷（cAMP）β受体水平。结果与文献中的现有数据一致，文献表明，使用血管紧张素转换酶（ACE）抑制剂可降低外周血管阻力，并通过体积描记法评估增加血流量。如阿加比蒂 - 罗斯（1）所报道，服用卡托普利一年后也记录到了类似结果。在静息血流量和静息外周血管阻力方面，给予安慰剂的高血压患者和给予依那普利四周的高血压患者之间检测到了统计学上的显著差异。在比较高血压患者和正常血压受试者时也存在显著差异。结果以表格和图表形式呈现。
