近期对Gro/TLE共抑制因子招募与功能的见解。
Recent insights into Groucho co-repressor recruitment and function.
作者信息
Kaul Aamna K, Schuster Eugene F, Jennings Barbara H
机构信息
a Department of Genetics, Evolution and Environment ; University College London ; London , United Kingdom.
出版信息
Transcription. 2015;6(1):7-11. doi: 10.1080/21541264.2014.1000709. Epub 2015 Jan 20.
Abstract
Gene expression is often controlled by transcriptional repressors during development. Many transcription factors lack intrinsic repressive activity but recruit co-factors that inhibit productive transcription. Here we discuss new insights and models for repression mediated by the Groucho/Transducin-Like Enhancer of split (Gro/TLE) family of co-repressor proteins.
摘要
在发育过程中，基因表达常常受到转录抑制因子的调控。许多转录因子缺乏内在的抑制活性，但会招募抑制有效转录的辅助因子。在此，我们讨论由共抑制蛋白Groucho/分裂样转导素增强子（Gro/TLE）家族介导的抑制作用的新见解和模型。
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