Giovannini M, Seitz J F, Rosello R, Gauthier A
Service de Gastroentérologie, Institut Paoli-Calmettes, Marseille.
Gastroenterol Clin Biol. 1989 Dec;13(12):974-7.
The effectiveness of ultrasonically guided percutaneous ethanol injection therapy was investigated in 8 patients who had hepatocellular carcinoma (two cases), hepatic metastases from colorectal carcinoma (five cases) and hepatic metastasis from breast carcinoma (one case). Tumor diameter was less than 5 cm in all cases. Fifty-nine ethanol injection were performed for 11 lesions. Histopathologic examination, performed in all cases, showed that the tumor was completely necrotic in 4 cases, partially necrotic in 3 cases and unchanged in 4 cases. Serum alphafetoprotein and carcinoembryogenic antigen decreased in 5 out of 8 cases. Seven patients were still alive at the end of the study with a mean follow-up period of 10.7 months. We conclude that ethanol injection may be a valuable treatment for small hepatic tumors.
对8例患有肝细胞癌(2例)、结直肠癌肝转移(5例)和乳腺癌肝转移(1例)的患者进行了超声引导下经皮乙醇注射治疗的有效性研究。所有病例肿瘤直径均小于5厘米。对11个病灶进行了59次乙醇注射。所有病例均进行了组织病理学检查,结果显示4例肿瘤完全坏死,3例部分坏死,4例无变化。8例中有5例血清甲胎蛋白和癌胚抗原下降。研究结束时,7例患者仍存活,平均随访期为10.7个月。我们得出结论,乙醇注射可能是治疗小肝肿瘤的一种有价值的方法。