拟南芥的全基因组分析揭示了AAAGN7CTTT基序的高频率。
Genome wide analysis of Arabidopsis thaliana reveals high frequency of AAAGN7CTTT motif.
作者信息
Mehrotra Rajesh, Jain Vishesh, Shekhar Chandra, Mehrotra Sandhya
机构信息
Department of Biological Sciences, Birla Institute of Technology & Sciences, Pilani, Rajasthan 333031, India ; Okinawa Institute of Science and Technology, Onna son, Okinawa, Japan.
Department of Biological Sciences, Birla Institute of Technology & Sciences, Pilani, Rajasthan 333031, India.
出版信息
Meta Gene. 2014 Aug 29;2:606-15. doi: 10.1016/j.mgene.2014.05.003. eCollection 2014 Dec.
Sequence specific elements in DNA regulate transcription by recruiting transcription factors. The Dof proteins are a large family of transcription factors that share a single highly conserved zinc finger. The core to which Dof proteins bind has a consensus AAAG or ACTTTA sequence. These motifs have been over represented in many promoters. We performed a genome wide analysis of AAAG repeat elements increasing the spacer length from 0 to 25. Similar analyses was done with AAAG-CTTT motifs. We report unusual high frequency of AAAGN7CTTT in Arabidopsis thaliana genome. We also conclude that there is a preference for A/G nucleotides in spacer sequence between two AAAG repeats.
DNA中的序列特异性元件通过招募转录因子来调节转录。Dof蛋白是一大类转录因子，它们共享一个高度保守的锌指结构。Dof蛋白结合的核心序列具有一致的AAAG或ACTTTA序列。这些基序在许多启动子中出现的频率过高。我们对AAAG重复元件进行了全基因组分析，将间隔长度从0增加到25。对AAAG-CTTT基序也进行了类似的分析。我们报告了拟南芥基因组中AAAGN7CTTT出现的频率异常高。我们还得出结论，两个AAAG重复序列之间的间隔序列中，A/G核苷酸存在偏好性。
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