Biscaro Andressa, Braga Antônio, Berkowitz Ross Stuart
Masters Degree Program in Maternal and Child Health, Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil.
Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil.
Rev Bras Ginecol Obstet. 2015 Jan;37(1):42-51. doi: 10.1590/SO100-720320140005198.
Gestational trophoblastic neoplasia (GTN) is the term to describe a set of malignant placental diseases, including invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Both invasive mole and choriocarcinoma respond well to chemotherapy, and cure rates are greater than 90%. Since the advent of chemotherapy, low-risk GTN has been treated with a single agent, usually methotrexate or actinomycin D. Cases of high-risk GTN, however, should be treated with multiagent chemotherapy, and the regimen usually selected is EMA-CO, which combines etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine. This study reviews the literature about GTN to discuss current knowledge about its diagnosis and treatment.
妊娠滋养细胞肿瘤（GTN）是描述一组恶性胎盘疾病的术语，包括侵蚀性葡萄胎、绒毛膜癌、胎盘部位滋养细胞肿瘤和上皮样滋养细胞肿瘤。侵蚀性葡萄胎和绒毛膜癌对化疗反应良好，治愈率超过90%。自化疗问世以来，低风险GTN一直采用单一药物治疗，通常是甲氨蝶呤或放线菌素D。然而，高风险GTN病例应采用多药化疗，通常选择的方案是EMA-CO，它联合了依托泊苷、甲氨蝶呤、放线菌素D、环磷酰胺和长春新碱。本研究回顾了关于GTN的文献，以讨论其诊断和治疗的现有知识。
