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食用小龙虾后并发多器官功能衰竭的哈夫病:病例报告

Haff disease complicated by multiple organ failure after crayfish consumption: a case study.

作者信息

Feng Gang, Luo Qiancheng, Zhuang Ping, Guo Enwei, Yao Yulan, Gao Zhongyu

机构信息

Intensive Care Unit, Gongli Hospital, Second Military Medical University, Shanghai, China.

Office of Teaching, Gongli Hospital, Second Military Medical University, Shanghai, China.

出版信息

Rev Bras Ter Intensiva. 2014 Oct-Dec;26(4):407-9. doi: 10.5935/0103-507X.20140062.

DOI:10.5935/0103-507X.20140062
PMID:25607271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4304470/
Abstract

Haff disease is a syndrome consisting of unexplained rhabdomyolysis. Patients suffering from Haff disease report having eaten fish within 24 hours before the onset of illness. Most patients survive and recover quickly. The present study is the first report of Haff disease complicated by multiple organ failure after crayfish consumption. A 66-year-old Chinese man ate cooked crayfish on the night of June 23, 2013. He arrived at our hospital 2 days later and was admitted to the intensive care unit. After admission, the patient was diagnosed with Haff disease complicated by multiple organ failure. Despite supportive and symptomatic treatments, the condition of the patient deteriorated, and he died due to his illness. Haff disease is a rare clinical syndrome that is sometimes misdiagnosed. Early diagnosis and proper treatment are essential to prevent progression to multiple organ failure.

摘要

哈夫病是一种由不明原因的横纹肌溶解症组成的综合征。患有哈夫病的患者报告称在发病前24小时内食用过鱼类。大多数患者存活且恢复迅速。本研究是食用小龙虾后并发多器官功能衰竭的哈夫病的首例报告。一名66岁的中国男性于2013年6月23日晚食用了熟小龙虾。两天后他来到我院并被收入重症监护病房。入院后,该患者被诊断为并发多器官功能衰竭的哈夫病。尽管进行了支持性和对症治疗,但患者病情仍恶化,最终因病死亡。哈夫病是一种罕见的临床综合征,有时会被误诊。早期诊断和恰当治疗对于预防进展为多器官功能衰竭至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9874/4304470/d6dfed9f917f/rbti-26-04-0407-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9874/4304470/d6dfed9f917f/rbti-26-04-0407-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9874/4304470/d6dfed9f917f/rbti-26-04-0407-g01.jpg

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本文引用的文献

1
Haff disease associated with the ingestion of the freshwater fish Mylossoma duriventre (pacu-manteiga).与食用淡水鱼杜氏脂鲤(帕库食人鱼)相关的哈夫病。
Rev Bras Ter Intensiva. 2013 Oct-Dec;25(4):348-51. doi: 10.5935/0103-507X.20130058.
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Haff disease after eating crayfish in east China.中国东部食用小龙虾后出现哈夫病。
Intern Med. 2012;51(5):487-9. doi: 10.2169/internalmedicine.51.6786. Epub 2012 Mar 1.
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Outbreak of Haff disease in the Brazilian Amazon.巴西亚马逊地区哈夫病的爆发。
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Outbreak of Haff Disease along the Yangtze River, Anhui Province, China, 2016.2016 年中国安徽省沿长江地区发生赫夫病疫情。
Emerg Infect Dis. 2020 Dec;26(12):2916-2921. doi: 10.3201/eid2612.191186.
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Ionophore Toxin Maduramicin Produces Haff Disease-Like Rhabdomyolysis in a Mouse Model.离子载体毒素马杜霉素在小鼠模型中产生类似哈夫病的横纹肌溶解症。
Int J Environ Res Public Health. 2020 Oct 27;17(21):7882. doi: 10.3390/ijerph17217882.
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Braz J Infect Dis. 2019 Jul-Aug;23(4):278-280. doi: 10.1016/j.bjid.2019.06.011. Epub 2019 Jul 24.
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The Emergence and Epidemiology of Haff Disease in China.中国哈夫病的出现与流行病学
Toxins (Basel). 2016 Dec 1;8(12):359. doi: 10.3390/toxins8120359.
Rev Panam Salud Publica. 2009 Nov;26(5):469-70. doi: 10.1590/s1020-49892009001100012.
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Haff disease in Sweden.瑞典的哈夫病
Acta Med Scand. 1948 Feb 25;129(6):560-72. doi: 10.1111/j.0954-6820.1948.tb09326.x.
5
Haff disease after eating salmon.食用三文鱼后出现哈夫病。
South Med J. 2007 Nov;100(11):1147-50. doi: 10.1097/SMJ.0b013e3181583673.
6
Haff disease: from the Baltic Sea to the U.S. shore.哈夫病:从波罗的海到美国海岸。
Emerg Infect Dis. 2000 Mar-Apr;6(2):192-5. doi: 10.3201/eid0602.000215.
7
Tetrodotoxin poisoning associated with eating puffer fish transported from Japan--California, 1996.1996年加利福尼亚州与食用从日本运来的河豚相关的河豚毒素中毒事件
MMWR Morb Mortal Wkly Rep. 1996 May 17;45(19):389-91.