虾青素可改善实验性骨关节炎中的软骨损伤。
Astaxanthin ameliorates cartilage damage in experimental osteoarthritis.
作者信息
Huang Li-juan, Chen Wei-Ping
机构信息
a Department of Burn , The Second Affiliated Hospital of Medical College, Zhejiang University , Hangzhou , P. R. China.
出版信息
Mod Rheumatol. 2015 Sep;25(5):768-71. doi: 10.3109/14397595.2015.1008724. Epub 2015 Jun 12.
PURPOSE
Astaxanthin is a red-pigment carotenoid found in certain marine animals and plants. Astaxanthin has been shown to inhibit matrix metalloproteinases (MMPs) expression in vitro. However, the effect of astaxanthin on cartilage is still unclear. The aim of this study was to investigate the effects of astaxanthin on cartilage in experimental osteoarthritis (OA).
METHODS
New Zealand rabbits underwent anterior cruciate ligament transection to induce OA in right knee. Rabbits received intra-articular injection containing 0.3 ml of vehicle (dimethyl sulfoxide) or astaxanthin (50 μM). Injection was started on the day of operation, and the injection were performed once weekly for six consecutive weeks. Then, rabbits were sacrificed and the right knees were harvested for study.
RESULTS
Cartilage degradation was reduced by astaxanthin, as assessed by morphological and histological examination. Astaxanthin inhibited the gene expression of MMP-1, MMP-3, and MMP-13 in cartilage as compared with the vehicle group.
CONCLUSIONS
The results suggest that astaxanthin may be considered as pharmaceutical agent in OA treatment.
目的
虾青素是一种存在于某些海洋动植物中的红色色素类胡萝卜素。已表明虾青素在体外可抑制基质金属蛋白酶（MMPs）的表达。然而，虾青素对软骨的影响仍不明确。本研究的目的是探讨虾青素在实验性骨关节炎（OA）中对软骨的作用。
方法
新西兰兔行右膝前交叉韧带切断术以诱导OA。兔接受关节内注射，注射含0.3 ml赋形剂（二甲基亚砜）或虾青素（50 μM）。于手术当天开始注射，连续六周每周注射一次。然后，处死兔并取出右膝用于研究。
结果
通过形态学和组织学检查评估，虾青素可减轻软骨降解。与赋形剂组相比，虾青素抑制软骨中MMP-1、MMP-3和MMP-13的基因表达。
结论
结果表明虾青素可被视为OA治疗的药物。
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