Gun'ko S V, Zaporozhan V N, Gun'ko V A, Nizova N N
Vopr Med Khim. 1989 Nov-Dec;35(6):78-9.
A decrease in activity of Na+, K(+)-ATPase, estimated in erythrocytes of women at the second half of pregnancy, served as a criterion in screening of the risk group tended to development of late toxicoses. In the risk group of women with pregnancy activity of glutathione peroxidase and content of selenium were studied in blood, simultaneously with estimation of osmotic resistance of erythrocytes. A decrease in activity of Na+, K(+)-ATPase was shown to be a reliable prognostic criterion in pregnant women with tendency to late toxicoses. At the same time, a decrease in glutathione peroxidase activity should be used as a distinct prognostic pattern only if content of selenium was as low as 95 pg/ml in blood of women with pregnancy. Alimentary and metabolic deficiency of selenium appears to be responsible for limitation of the glutathione peroxidase activity at the preclinical step of late toxicosis development.
通过测定妊娠后半期女性红细胞中Na + ，K(+)-ATP酶的活性降低，作为筛查有发生晚期中毒倾向风险组的标准。在有妊娠风险的女性组中，研究了血液中谷胱甘肽过氧化物酶的活性和硒含量，同时评估了红细胞的渗透抗性。结果表明，Na + ，K(+)-ATP酶活性降低是有晚期中毒倾向孕妇的可靠预后标准。同时，只有当妊娠女性血液中硒含量低至95 pg/ml时，谷胱甘肽过氧化物酶活性降低才应作为一个明显的预后指标。硒的营养和代谢缺乏似乎是晚期中毒发生临床前阶段谷胱甘肽过氧化物酶活性受限的原因。
