Grozdova I D, Klimov N P, Mamaeva E G, Krekhnov B V, Sveshnikova E V, Ivashkin V T, Vasil'ev V Iu, Severin E S
Vopr Med Khim. 1989 Nov-Dec;35(6):83-7.
Activity of cAMP-dependent and -independent protein kinases as well as content of cAMP were studied in biopsy preparations of gastric mucosal membranes obtained from patients with superficial gastritis, erosion, ulcer, adenomatous polyps and ulcer after treatment with laser irradiation. All the patterns studied were similar in preparations of adenomatous polyps and normal mucosal membrane. Activity of cAMP-independent protein kinases was increased under conditions of erosion, ulcer, gastroduodenal reflux and, especially, in ulcer tissue treated with laser. However, the ratio between cAMP-independent and -dependent phosphorylation was increased only in 50% of ulcerous diseases and in gastroduodenal reflux. The equilibrium of cAMP-dependent and -independent phosphorylation was not altered in the other impairments studied even though benign proliferation was stimulated using laser irradiation.
对取自患有浅表性胃炎、糜烂、溃疡、腺瘤性息肉的患者以及激光照射治疗后的溃疡患者的胃黏膜活检标本，研究了环磷酸腺苷（cAMP）依赖性和非依赖性蛋白激酶的活性以及cAMP的含量。在腺瘤性息肉和正常黏膜标本中，所有研究模式均相似。在糜烂、溃疡、胃十二指肠反流的情况下，尤其是激光治疗后的溃疡组织中，cAMP非依赖性蛋白激酶的活性增加。然而，仅在50%的溃疡性疾病和胃十二指肠反流中，cAMP非依赖性与依赖性磷酸化之间的比率增加。即使使用激光照射刺激良性增殖，在其他所研究的损伤中，cAMP依赖性和非依赖性磷酸化的平衡也未改变。
