Department of Chemistry and Biochemistry, University of Arkansas , Fayetteville, Arkansas 72701, United States.
Anal Chem. 2015 Feb 17;87(4):2029-32. doi: 10.1021/ac5042022. Epub 2015 Jan 26.
The electrochemical redox cycling (RC) behavior of individual and binary mixtures of three catecholamines are investigated using gold microelectrode arrays in vitro. Catecholamines showed reversible or irreversible responses during RC depending on their oxidation products' cyclization rate. The RC behavior of the binary mixtures supports the disproportionation reaction of catecholamines, which has been previously reported, but not under RC conditions or with mixtures. This fundamental study provides insights on the effects of complicated mechanisms and kinetics on RC and sets the foundation for future applications of RC for in vivo multi-neurotransmitter analysis.
采用金微电极阵列在体外研究了三种儿茶酚胺的单一组分和二元混合物的电化学氧化还原循环（RC）行为。儿茶酚胺在 RC 过程中表现出可逆或不可逆响应，这取决于其氧化产物的环化速率。二元混合物的 RC 行为支持儿茶酚胺的歧化反应，这在之前的研究中已经有报道，但不是在 RC 条件下或混合物中。这项基础研究深入了解了复杂机制和动力学对 RC 的影响，并为未来 RC 在体内多神经递质分析中的应用奠定了基础。
