Yamamoto C
Rinsho Shinkeigaku. 1989 Dec;29(12):1526-8.
After a brief tetanic stimulation of an excitatory pathway in the hippocampus, synaptic transmission through the tetanized pathway is facilitated for a long period. This phenomenon is called long-term potentiation (LTP), and has been regarded as a neuronal correlate with learning and memory. Features of LPT in Schaffer collateral-CA1 neuron are calcium-dependency, input-specificity, cooperativity and sensitivity to blockers of N-methyl-D-aspartate (NMDA) receptors. These features can be explained by properties of NMDA receptors. LTP in mossy fiber-CA3 neuron has features different from those in field CA1: It is insensitive to blockers of NMDA receptors and does not show cooperativity. Quantal analysis of transmission through mossy fiber synapses before and after generation of LTP reveals that LTP resulted from facilitated release of transmitter. Participation of the metabotropic glutamate receptor is suggested.
在对海马体中的一条兴奋性通路进行短暂强直刺激后，通过该受刺激通路的突触传递会在很长一段时间内得到促进。这种现象被称为长时程增强（LTP），并且一直被视为与学习和记忆相关的神经元关联。海马体联合纤维-CA1神经元中长时程增强的特征包括钙依赖性、输入特异性、协同性以及对N-甲基-D-天冬氨酸（NMDA）受体阻滞剂的敏感性。这些特征可以用NMDA受体的特性来解释。苔藓纤维-CA3神经元中的长时程增强具有与CA1区不同的特征：它对NMDA受体阻滞剂不敏感，并且不表现出协同性。对长时程增强产生前后通过苔藓纤维突触的传递进行量子分析表明，长时程增强是由递质释放的促进所导致的。提示了代谢型谷氨酸受体的参与。
