舌下含服硝酸异山梨酯直立倾斜试验在儿童血管迷走性晕厥诊断中的应用
Head-up tilt table testing with sublingual isosorbide dinitrate in the diagnosis of vasovagal syncope in children.
作者信息
Karacan Mehmet, Olgun Hasim, Ceviz Naci
机构信息
Atatürk University, Faculty of Medicine, Department of Pediatric Cardiology, Erzurum, Turkey.
出版信息
Eurasian J Med. 2008 Dec;40(3):115-8.
OBJECTIVE
To evaluate the effect of sublingual administration of ISDN on the results of the head-up tilt table test (HUTT) in children and adolescents with vasovagal syncope.
MATERIALS AND METHODS
The study group consisted of 30 children, each with at least one incidence of vasovagal syncope, and the control group had 15 healthy children. The patients were tilted upright at an angle of 60° for 15 minutes. If the test was negative, sublingual ISDN was administered and the test was continued for an additional 15 minutes.
RESULTS
The sensitivity and specificity of the basal test were 30% and 100%, respectively. Although the specificity decreased somewhat (93.3%) after sublingual ISDN, the sensitivity significantly increased to 96.7%. No severe complications were observed after sublingual ISDN administration.
CONCLUSION
Our results suggested that sublingual ISDN is a useful, effective and safe agent for pharmacologic stimulation and measurement of the HUTT in children. It increased the sensitivity of the test with a slight decrease in specificity.
目的
评估舌下含服硝酸异山梨酯（ISDN）对血管迷走性晕厥儿童及青少年直立倾斜试验（HUTT）结果的影响。
材料与方法
研究组由30名儿童组成，每名儿童至少有一次血管迷走性晕厥发作，对照组有15名健康儿童。患者以60°角直立倾斜15分钟。若试验为阴性，则舌下含服ISDN，并继续试验15分钟。
结果
基础试验的敏感性和特异性分别为30%和100%。舌下含服ISDN后，特异性虽略有下降（93.3%），但敏感性显著提高至96.7%。舌下含服ISDN后未观察到严重并发症。
结论
我们的结果表明，舌下含服ISDN是用于儿童药理刺激和HUTT测量的一种有用、有效且安全的药物。它提高了试验的敏感性，特异性略有下降。
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