Kara Murat, Sen Askin, Cetin Esin Sakallı, Kargun Kursat
Department of Medical Genetics, Mugla Sitki Kocman University Faculty of Medicine, Mugla, Turkey.
Department of Medical Genetics, Firat University Hospital Faculty of Medicine, Elazig, Turkey.
Eurasian J Med. 2014 Oct;46(3):220-3. doi: 10.5152/eajm.2014.33. Epub 2014 Jul 8.
Chromosomal rearrangements are usually associated with male factor infertility. We report here a 34-year-old man suffering from primary infertility for 15 years. The cytogenetic analysis and investigation of Y-chromosome microdeletions were performed. A reciprocal balanced translocation t (10;19) (q11.2;q13.4) was found in oligozoospermic infertile men with no Y-chromosome microdeletions. In this case, we aimed to evaluate the 46,XY,t (10;19) (q11.2;q13.4) karyo-type, which was detected through a cytogenetic analysis of a person referred to our genetic laboratory due to primary infertility, in the light of the literature.
染色体重排通常与男性因素不育相关。我们在此报告一名34岁男性,患有原发性不育症15年。进行了细胞遗传学分析和Y染色体微缺失检测。在无Y染色体微缺失的少精子症不育男性中发现了相互平衡易位t(10;19)(q11.2;q13.4)。在本病例中,我们旨在根据文献评估通过对因原发性不育转诊至我们遗传实验室的一名患者进行细胞遗传学分析检测到的46,XY,t(10;19)(q11.2;q13.4)核型。