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昼夜节律时钟蛋白在情绪调节中的作用

Circadian clock proteins in mood regulation.

作者信息

Partonen Timo

机构信息

Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare , Helsinki , Finland.

出版信息

Front Psychiatry. 2015 Jan 6;5:195. doi: 10.3389/fpsyt.2014.00195. eCollection 2014.

DOI:10.3389/fpsyt.2014.00195
PMID:25610405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4285016/
Abstract

Mood regulation is known to be affected by the change of seasons. Recent research findings have suggested that mood regulation may be influenced by the function of circadian clocks. In addition, the activity of brown adipocytes has been hypothesized to contribute to mood regulation. Here, the overarching link to mood disorders might be the circadian clock protein nuclear receptor subfamily 1, group D, member 1.

摘要

众所周知,情绪调节会受到季节变化的影响。最近的研究结果表明,情绪调节可能受生物钟功能的影响。此外,有人推测褐色脂肪细胞的活动有助于情绪调节。在此,与情绪障碍的总体联系可能是生物钟蛋白核受体亚家族1 D组成员1。

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本文引用的文献

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The circadian system of patients with bipolar disorder differs in episodes of mania and depression.双相情感障碍患者的昼夜节律系统在躁狂和抑郁发作时有所不同。
Bipolar Disord. 2015 May;17(3):303-14. doi: 10.1111/bdi.12270. Epub 2014 Oct 31.
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IRF4 is a key thermogenic transcriptional partner of PGC-1α.IRF4 是 PGC-1α 的关键产热转录伴侣。
Cell. 2014 Jul 3;158(1):69-83. doi: 10.1016/j.cell.2014.04.049.
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The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis.核受体REV-ERBα调节脂肪酸结合蛋白7(Fabp7)并调控成体海马神经发生。
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The brain and brown fat.大脑与棕色脂肪。
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Molecular mechanisms of the circadian clockwork in mammals.哺乳动物生物钟的分子机制。
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Impact of circadian nuclear receptor REV-ERBα on midbrain dopamine production and mood regulation.生物钟核受体 REV-ERBα 对中脑多巴胺产生和情绪调节的影响。
Cell. 2014 May 8;157(4):858-68. doi: 10.1016/j.cell.2014.03.039.
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Circadian regulation of Tshb gene expression by Rev-Erbα (NR1D1) and nuclear corepressor 1 (NCOR1).Rev-Erbα(NR1D1)和核共抑制因子1(NCOR1)对Tshb基因表达的昼夜节律调节。
J Biol Chem. 2014 Jun 13;289(24):17070-7. doi: 10.1074/jbc.M114.569723. Epub 2014 May 2.
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Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα.缺乏核受体Rev-erbα的小鼠的行为变化和多巴胺能失调
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The nuclear receptor Rev-erbα controls circadian thermogenic plasticity.核受体 Rev-erbα 控制昼夜节律性产热的可塑性。
Nature. 2013 Nov 21;503(7476):410-413. doi: 10.1038/nature12642. Epub 2013 Oct 27.
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CRY2 genetic variants associate with dysthymia.CRY2 基因变异与心境恶劣有关。
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