Dupont J, Rodes J F, Berreur-Bonnenfant J, Carre M C, Tekitek A, Berreur P
UA 1180-CNRS Laboratoire de Biologie Végétale VI, Université P. et M. Curie, Paris, France.
Biol Cell. 1989;67(2):141-6.
Farnesylacetone (C18 H30 0) is a male hormone extracted from the androgenic gland of crab, Carcinus maenas. Appropriate enzymatic assays, as well as spectrophotometric studies, indicate that micromolar concentrations of farnesylacetone interact with the electron transport pathway of rat liver mitochondria. By the use of artificial electron donors and electron acceptors, it is shown that farnesylacetone immediately inhibits the electron transfer within complex I (NADH ubiquinone reductase activity) and complex II (succinate ubiquinone reductase activity). It is proposed that farneylacetone could interact with these two complexes of the respiratory chain at the level of the iron-sulfur centers implicated in the dehydrogenase activities. These observations are compared with the results obtained with terpenic molecules which interact with mitochondrial respiration.
法尼基丙酮（C₁₈H₃₀O）是从绿蟹（Carcinus maenas）的雄性腺中提取的一种雄性激素。适当的酶促分析以及分光光度研究表明，微摩尔浓度的法尼基丙酮与大鼠肝脏线粒体的电子传递途径相互作用。通过使用人工电子供体和电子受体，结果表明法尼基丙酮会立即抑制复合物I（NADH泛醌还原酶活性）和复合物II（琥珀酸泛醌还原酶活性）内的电子传递。有人提出，法尼基丙酮可能在与脱氢酶活性相关的铁硫中心水平上与呼吸链的这两个复合物相互作用。将这些观察结果与用与线粒体呼吸相互作用的萜类分子获得的结果进行了比较。
