Lu Z L, Shi Y F, Fan X M
Zhonghua Nei Ke Za Zhi. 1989 Nov;28(11):642-5, 699.
A 35-year male patient with clinical and biochemical manifestations of severe hypercorticism was thought to have Cushing's syndrome of pituitary origin. However, the surgically removed pituitary adenoma was not confirmed by pathological examination. There was no improvement after transsphenoidal microsurgery Chest CT scan showed a small mass located at the upper-lobe of the right lung. This tumor (1.8 x 1.0 x 1.0 cm) was removed and one course of radiotherapy with linear accelerator was given. Remission was achieved clinically and biochemically after these therapies. The diagnosis of bronchial carcinoid was confirmed by pathological findings. Metastasis of a lymph node was also proved. The tumor cells was found to contain ACTH and related peptides with radioimmunoassay, immunocytochemistry and electron microscopy. Gel filtration of the tumor extracts showed molecular heterogeniety of ACTH related peptides and that the big-form were in large percentage.
一名35岁男性患者，有严重皮质醇增多症的临床和生化表现，被认为患有垂体源性库欣综合征。然而，手术切除的垂体腺瘤经病理检查未得到证实。经蝶窦显微手术后病情无改善。胸部CT扫描显示右肺上叶有一个小肿块。切除了这个肿瘤（1.8×1.0×1.0厘米），并给予直线加速器一个疗程的放疗。这些治疗后在临床和生化方面均实现缓解。病理结果证实为支气管类癌。还证实有淋巴结转移。通过放射免疫测定、免疫细胞化学和电子显微镜检查发现肿瘤细胞含有促肾上腺皮质激素（ACTH）及相关肽。肿瘤提取物的凝胶过滤显示ACTH相关肽具有分子异质性，且大分子形式占很大比例。
