Takeshita T, Kawahara M, Fujii K, Kinoshita H, Morio M
Division of Dental Anesthesia, Hiroshima University Dental Hospital, Japan.
Lymphology. 1989 Dec;22(4):194-8.
The effects of halothane on alpha-adrenergic receptors, beta-adrenergic receptors, and the process of Ca++ dependent contractions on rat mesenteric lymphatics were examined. Halothane depressed the contraction rate of mesenteric lymphatics but did not effect the increase in lymphatic contraction rate caused by noradrenaline (an alpha-agonist). The depressant effect of halothane on the contraction rate was also not antagonized by propranolol (a beta-blocker), but was partly reversed by CaCl2. These findings suggest that the depressant effect of halothane on the lymphatic contraction rate derives not from blocking lymphatic alpha-receptors or stimulating lymphatic beta-receptors but rather by halothane inhibition on the process of Ca++ dependent lymphatic contractions.
研究了氟烷对大鼠肠系膜淋巴管α-肾上腺素能受体、β-肾上腺素能受体以及Ca++依赖性收缩过程的影响。氟烷降低了肠系膜淋巴管的收缩速率，但不影响去甲肾上腺素（一种α-激动剂）引起的淋巴管收缩速率增加。氟烷对收缩速率的抑制作用也不受普萘洛尔（一种β-阻滞剂）的拮抗，但CaCl2可部分逆转这种作用。这些发现表明，氟烷对淋巴管收缩速率的抑制作用并非源于阻断淋巴管α-受体或刺激淋巴管β-受体，而是由于氟烷对Ca++依赖性淋巴管收缩过程的抑制。
