Tatum E T, Sun P C, Cohn D L
Department of Pathology, University of Colorado Health Sciences Center, Denver.
Pathology. 1989 Oct;21(4):235-8. doi: 10.3109/00313028909061066.
We describe a patient with the acquired immunodeficiency syndrome who suffered a colon perforation which we believe was directly attributable to disseminated cytomegalovirus (CMV) infection. Thrombosed vessels within the submucosa and muscle wall contained evidence of CMV vasculitis, while adjacent vessels without viral inclusions were fully patent. This report supports other evidence that CMV may act as a primary etiologic agent of gastrointestinal disease, particularly in the immunocompromised host. The increased recognition of CMV as a cause of significant morbidity in certain gastrointestinal lesions becomes especially important with the advent of newer antiviral therapy specifically directed against CMV infection.
我们描述了一名获得性免疫缺陷综合征患者，该患者发生了结肠穿孔，我们认为这直接归因于播散性巨细胞病毒（CMV）感染。黏膜下层和肌壁内形成血栓的血管有CMV血管炎的证据，而相邻没有病毒包涵体的血管则完全通畅。本报告支持其他证据，即CMV可能是胃肠道疾病的主要病因，尤其是在免疫功能低下的宿主中。随着专门针对CMV感染的新型抗病毒疗法的出现，CMV作为某些胃肠道病变中显著发病原因的认识增加变得尤为重要。
