Vanin A F, Kubrina L N, Kurbanov I S, Mordvintsev P I, Khrapova N V, Galagan M E, Matkhanov E I
Biokhimiia. 1989 Dec;54(12):1974-9.
Citrate iron complex injections to mice or rats resulted in the nitric oxide formation detected by nitric oxide binding to iron-diethyldithiocarbomate complexes. The mononitrosyl iron complexes formed were paramagnetic and EPR active. The maximal nitric oxide concentrations in rat livers were 15-20 nm per gram of tissue. Phenosan-K (an antioxidant) inhibited partly the iron capacity to nitric oxide formation in animal organisms. The nitric oxide formation was proposed to be due to some endogenic amino groups oxidation by active oxygen agents or products of lipid or non-saturated fatty acid production under the prooxidant action of the iron.
向小鼠或大鼠注射柠檬酸铁络合物会导致一氧化氮的生成，这可通过一氧化氮与二乙基二硫代氨基甲酸盐铁络合物结合来检测。形成的单亚硝基铁络合物具有顺磁性且具有电子顺磁共振活性。大鼠肝脏中一氧化氮的最大浓度为每克组织15 - 20纳米。非诺沙星 - K（一种抗氧化剂）部分抑制了动物体内铁生成一氧化氮的能力。一氧化氮的生成被认为是由于在铁的促氧化作用下，活性氧剂或脂质或不饱和脂肪酸产物氧化了一些内源性氨基所致。
