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[环磷酸腺苷、钙调蛋白依赖性刺激与心肌肌浆网钙转运对蛋白水解的稳定性]

[cAMP, calmodulin-dependent stimulation and stability to proteolysis of Ca 2+ transport in the heart sarcoplasmic reticulum].

作者信息

Antipenko A E, Sviderskaia E V, Dizhe G P, Krasnovskaia I E

出版信息

Biokhimiia. 1989 Dec;54(12):2023-9.

PMID:2561265
Abstract

The calmodulin content in cardiomyocyte cytosol of hypoxic myocardium is increased compared to normal level. This is unaccompanied by differences in the stimulating effect of calmodulin on Ca2+ transport in sarcoplasmic reticulum (SR) of ischemic heart. The decrease of the endogenous cAMP-dependent protein kinase activity in ischemia is associated with the lowered resistance to trypsinolysis of Ca2+ transport in SR (trypsin/microsomal protein ratio is 1:10) with simultaneous Ca-ATPase activation. In the presence of exogenous protein kinase and cAMP the protective effect of phosphorylation on Ca2+ transport in SR vesicles of hypoxic cardiomyocytes treated with trypsin for 10 min reaches the same level as in intact heart.

摘要

与正常水平相比，缺氧心肌细胞胞质溶胶中的钙调蛋白含量增加。这与钙调蛋白对缺血心脏肌浆网（SR）中Ca2+转运的刺激作用差异无关。缺血时内源性cAMP依赖性蛋白激酶活性的降低与SR中Ca2+转运对胰蛋白酶消化的抵抗力降低有关（胰蛋白酶/微粒体蛋白比为1:10），同时Ca-ATP酶被激活。在外源蛋白激酶和cAMP存在的情况下，用胰蛋白酶处理10分钟的缺氧心肌细胞SR囊泡中，磷酸化对Ca2+转运的保护作用达到与完整心脏相同的水平。

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1
[cAMP, calmodulin-dependent stimulation and stability to proteolysis of Ca 2+ transport in the heart sarcoplasmic reticulum].[环磷酸腺苷、钙调蛋白依赖性刺激与心肌肌浆网钙转运对蛋白水解的稳定性]
Biokhimiia. 1989 Dec;54(12):2023-9.
2
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