Berrani H, Vasies I, Cron J, Bachy B, Le Dosseur P, Mouterde O
Department of pediatrics, Rouen University Hospital, 76031 Rouen cedex, France.
Pediatric surgery, Rouen University Hospital, 76031 Rouen cedex, France.
Arch Pediatr. 2015 Mar;22(3):300-2. doi: 10.1016/j.arcped.2014.12.007. Epub 2015 Jan 19.
Inspissated bile syndrome (IBS) is a rare neonatal disease. In the majority of cases, it resolves spontaneously and treatment is conservative. Follow-up is recommended with close monitoring of laboratory tests. When IBS does not resolve spontaneously, a catheter can be inserted into the gallbladder for cholangiography, which allows irrigation and drainage. Despite this treatment, some biliary tract obstruction may persist. We report on the case of a 3-month-old infant whose continuous biliary obstruction caused by IBS was successfully managed by interventional radiology with the association of N-acetylcysteine and glucagon. Even as first-line agents, these would allow more rapid clearance of gallstones and prevent infectious complications of indwelling catheters as well as decrease the need for surgery.
浓缩胆汁综合征（IBS）是一种罕见的新生儿疾病。在大多数情况下，它会自发缓解，治疗以保守为主。建议进行随访并密切监测实验室检查。当IBS不能自发缓解时，可将导管插入胆囊进行胆管造影，以便冲洗和引流。尽管进行了这种治疗，一些胆道梗阻可能仍然存在。我们报告了一例3个月大的婴儿，其由IBS引起的持续性胆道梗阻通过介入放射学联合N-乙酰半胱氨酸和胰高血糖素成功得到治疗。即使作为一线药物，这些药物也能更快地清除胆结石，预防留置导管的感染并发症，并减少手术需求。
