使用病毒感染的靶细胞进行免疫疗法和增强抗体依赖性细胞介导的细胞毒性。
Immunotherapy and enhanced antibody-dependent cell-mediated cytotoxicity using virally-infected target cells.
作者信息
Bosse D, Ades E W
机构信息
Biological Products Branch, Centers for Disease Control, Atlanta, GA 30333.
出版信息
J Clin Lab Immunol. 1989 Jul;29(3):109-10.
PMID:2561291
Abstract
We examined the ability of in vitro addition of Interleukin-2 (IL-2) to differentially enhance antibody-dependent cell mediated cytotoxicity (ADCC) utilizing cultured Epstein-Barr virus infected cells and gammaglobulin (Sandoglobulin). We found significant enhancement of ADCC when IL-2 was added. Chronic Epstein-Barr virus or Chronic Fatigue Syndrome patients in a therapeutic gammaglobulin program may benefit from IL-2 given in vivo.
摘要
我们利用培养的感染爱泼斯坦-巴尔病毒的细胞和丙种球蛋白（桑多球蛋白），研究了体外添加白细胞介素-2（IL-2）对差异增强抗体依赖性细胞介导的细胞毒性（ADCC）的能力。我们发现添加IL-2时ADCC有显著增强。接受丙种球蛋白治疗方案的慢性爱泼斯坦-巴尔病毒感染或慢性疲劳综合征患者可能从体内给予IL-2中获益。
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