Ping Bao-Hong, Yue Chun-Yan, Zhu Yang-Min, Gao Ya, Wu Bin, Hong Jia-Qiong
Huiqiao Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2015 Jan;35(1):129-32.
We report two cases of rituximab (RTX)-induced interstitial pneumonia in two lymphoma patients receiving RTX treatment. Interstitial pneumonia was successfully managed in these two cases after a one-week-long intervention with corresponding treatments without affecting further treatment of the primary disease. RTX-induced interstitial pneumonia is characterized by a latent onset with an unclear pathological mechanism and absence of typical symptoms. High-resolution CT scan can provide valuable evidence for early diagnosis of RTX-induced interstitial pneumonia, which might be attributed partially to an increased susceptibility to P. jirovecii and fungal infection due to prolonged RTX treatment.
我们报告了两例接受利妥昔单抗（RTX）治疗的淋巴瘤患者发生RTX诱导的间质性肺炎的病例。在这两例患者中，经过为期一周的相应治疗干预，间质性肺炎得到了成功控制，且未影响原发性疾病的进一步治疗。RTX诱导的间质性肺炎的特点是起病隐匿，病理机制不明，且缺乏典型症状。高分辨率CT扫描可为RTX诱导的间质性肺炎的早期诊断提供有价值的证据，这可能部分归因于长期RTX治疗导致对耶氏肺孢子菌和真菌感染的易感性增加。
