Wender M, Tokarz-Kupczyk E, Mularek O
Katedry Neurologii AM w Poznaniu.
Neurol Neurochir Pol. 1989 May-Jun;23(3):188-92.
A group of 16 patients with secondary chronic progression of multiple sclerosis treated by short-lasting intensive immunosuppression (cyclophosphamide with ACTH) by the programme of Hausser et al (4) was compared with a clinically similar group of 16 patients treated exclusively with intramuscular ACTH. During 2 years of observation of the patients it was observed that short-lasting intensive immunosuppression induced with simultaneous administration of cyclophosphamide and ACTH had no beneficial effect on the slowly progressing form of multiple sclerosis. The observation leads to the conclusion that cyclophosphamide therapy should not be used in view of absence of favourable effect on the course of multiple sclerosis and the risk of increased frequency of malignant neoplasms which cannot be ruled out in this method.
将一组16例采用豪泽等人（4）的方案进行短期强化免疫抑制（环磷酰胺联合促肾上腺皮质激素）治疗的继发性慢性进展型多发性硬化患者，与另一组16例仅接受肌肉注射促肾上腺皮质激素治疗的临床症状相似的患者进行了比较。在对这些患者进行2年的观察期间，发现同时给予环磷酰胺和促肾上腺皮质激素诱导的短期强化免疫抑制对缓慢进展型多发性硬化没有有益效果。该观察结果得出结论，鉴于对多发性硬化病程没有有利影响且无法排除该方法中恶性肿瘤发生频率增加的风险，不应使用环磷酰胺治疗。
