Hadházy C, László M B
Arch Ital Anat Embriol. 1989 Jul-Sep;94(3):263-6.
A consistent chondrogenesis takes place in micro-mass cultures of stage 23-24 chicken limb bud mesenchymal cells. In these cultures a short, marked elevation of cAMP level was detected at the time of the onset of cartilage phenotype expression. On the other hand, exogeneous glycosaminoglycans which inhibited chondrogenesis caused a reduction in the cAMP level of the cells. These correlations between cAMP level and phenotypic characteristics suggest that, among other things required in chondrogenesis, cAMP level may be a prominent factor.
在第23 - 24阶段鸡胚肢体芽间充质细胞的微团培养中发生了持续的软骨形成。在这些培养物中，在软骨表型表达开始时检测到cAMP水平短暂且显著升高。另一方面，抑制软骨形成的外源性糖胺聚糖导致细胞cAMP水平降低。cAMP水平与表型特征之间的这些相关性表明，在软骨形成所需的其他因素中，cAMP水平可能是一个重要因素。
