Hardebo J E, Kåhrström J, Owman C, Salford L G
Department of Medical Cell Research, University of Lund, Sweden.
Blood Vessels. 1989;26(5):249-53. doi: 10.1159/000158774.
Endothelin, a peptide produced in endothelial cells, was found to be a potent constrictor of human pial arteries through a direct, slow action on the smooth muscle cell, with a pD2 value of 8.54. It was less potent as a constrictor in pial veins (pD2 7.80) and in branches of the middle meningeal artery and superficial temporal artery (pD2 7.61 and 7.77). The major component of the contractile response in the arteries comprises an effect on potential-operated calcium channels, as evidenced by tests with nimodipine. Endothelin may regulate intracranial vessels tonically during physiological as well as pathophysiological conditions.
内皮素是一种在内皮细胞中产生的肽，通过对平滑肌细胞的直接、缓慢作用，被发现是人类软脑膜动脉的强效收缩剂，其pD2值为8.54。它在软脑膜静脉（pD2 7.80）以及脑膜中动脉和颞浅动脉分支（pD2 7.61和7.77）中作为收缩剂的效力较低。动脉收缩反应的主要成分包括对电压门控钙通道的影响，尼莫地平试验证明了这一点。内皮素可能在生理和病理生理条件下对颅内血管进行紧张性调节。
