Ibrahim N D, Rahamathulla P M, Njoku C O
Int J Parasitol. 1989 Dec;19(8):915-8. doi: 10.1016/0020-7519(89)90119-7.
Hepatozoonosis is a very important disease in dogs in Nigeria. Hepatozoonosis was reported in Nigeria in 18 dogs. The clinical signs included fever, anorexia, loss of weight, lameness, oculonasal discharge and conjunctivitis. Hematologic findings included leukocytosis due to neutrophilia and eosinophilia. Parasitemia varied from 1 to 9% of the circulating neutrophils in the peripheral blood smears of the dogs examined. Hepatozoon canis gametocytes were identified in circulating neutrophils of dogs. Peripheral blood smears from dogs confirmed to have natural H. canis infection were cytochemically stained for myeloperoxidase. Parasitized neutrophils were myeloperoxidase deficient while non-parasitized neutrophils were myeloperoxidase positive. This is considered important, because deficiency of the enzyme may be responsible for poor response of H. canis to chemotherapeutic agents.
肝簇虫病在尼日利亚的犬类中是一种非常重要的疾病。1964年在尼日利亚报道了18只犬感染肝簇虫病。临床症状包括发热、厌食、体重减轻、跛行、眼鼻分泌物增多和结膜炎。血液学检查结果包括因嗜中性粒细胞增多和嗜酸性粒细胞增多导致的白细胞增多。在所检查犬只的外周血涂片上，虫血症在外周循环嗜中性粒细胞中占比从1%到9%不等。在犬类循环嗜中性粒细胞中鉴定出犬肝簇虫配子体。对确诊感染自然犬肝簇虫的犬只外周血涂片进行髓过氧化物酶细胞化学染色。被寄生的嗜中性粒细胞髓过氧化物酶缺乏，而未被寄生的嗜中性粒细胞髓过氧化物酶呈阳性。这一点被认为很重要，因为该酶的缺乏可能是犬肝簇虫对化疗药物反应不佳的原因。
