艾米利亚-罗马涅地区开放性脊柱裂的产前诊断
Prenatal diagnosis of open spina bifida in Emilia-Romagna.
作者信息
Ghi Tullio, Cocchi Guido, Conti Letizia, Pacella Giuseppina, Youssef Aly, Rizzo Nicola, Pilu Gianluigi
机构信息
Department of Obstetrics and Gynecology, Sant'Orsola Malpighi University Hospital, Bologna, Italy.
出版信息
Fetal Diagn Ther. 2015;37(4):301-4. doi: 10.1159/000366158. Epub 2015 Jan 21.
OBJECTIVE
To report recent data on the epidemiology of pregnancies affected by open spina bifida in the Emilia-Romagna region of Italy.
METHODS
All cases of open spina bifida diagnosed in the Emilia-Romagna region between 2001 and 2011 and reported to the IMER regional registry were included in the study group. The pregnancy outcome was retrospectively assessed.
RESULTS
In the study period out of 390,978 babies born in Emilia-Romagna 126 cases of open spina bifida were reported to the IMER registry, resulting in a global prevalence of 3.2 per 10,000 births. Prenatal diagnosis was achieved in the vast majority of these cases (105/126; 83.3%) and in a great proportion of those women (85/105; 80.9%) who opted for termination of pregnancy.
CONCLUSIONS
In a wide region of northern Italy where ultrasound anomaly scan is routinely offered to the general population, the vast majority of cases of open spina bifida are diagnosed antenatally and terminated electively.
目的
报告意大利艾米利亚-罗马涅地区受开放性脊柱裂影响的妊娠流行病学的最新数据。
方法
研究组纳入了2001年至2011年间在艾米利亚-罗马涅地区诊断出并报告至IMER地区登记处的所有开放性脊柱裂病例。对妊娠结局进行回顾性评估。
结果
在研究期间，艾米利亚-罗马涅地区出生的390,978名婴儿中，有126例开放性脊柱裂病例报告至IMER登记处，全球患病率为每10,000例出生3.2例。这些病例中的绝大多数（105/126；83.3%）以及选择终止妊娠的大部分女性（85/105；80.9%）都实现了产前诊断。
结论
在意大利北部的一个广大地区，超声异常扫描已常规提供给普通人群，绝大多数开放性脊柱裂病例在产前被诊断出来并被选择性终止妊娠。
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