Karita K, Izumi H, Tabata T, Kuriwada S, Sasano T, Sanjo D
Proc Finn Dent Soc. 1989;85(4-5):289-94.
This study was carried out to investigate the nervous control of the blood flow in the periodontal ligament measured by laser Doppler flowmeter. Ten adult cats were anesthetized with pentobarbital sodium (initial dose of 30 mg/kg, i.v. and maintenance dose of 5 mg/kg, i.v.). After enucleating the left eye ball, the superior alveolar nerve was exposed. The bone overlying the labial aspect of the left maxillary canine tooth root was pared away until a transparent layer of bone was left covering the periodontal ligament. A laser light from a probe of the flowmeter fixed at the tooth was beamed through the thinned bone. Three different patterns of responses were observed following the electrical stimulation of the distal end of the cut superior alveolar nerve: an increasing, a decreasing and a biphasic change of blood flow. The application of capsaicin onto the superior alveolar nerve reduced the response of blood flow increase but had no effect on the response of blood flow decrease. On the other hand, the response of blood flow decrease was completely inhibited by the pretreatment with phentolamine while the response of blood flow increase was not affected. The present results suggest that blood flow in the periodontal ligament of cats is controlled by sympathetic alpha-adrenergic fibers for vasoconstriction and by sensory fibers for vasodilation.
本研究旨在通过激光多普勒血流仪研究牙周膜血流的神经控制。选用10只成年猫，用戊巴比妥钠麻醉（静脉注射初始剂量30mg/kg，维持剂量5mg/kg）。摘除左眼眼球后，暴露上牙槽神经。刮除左上颌犬齿牙根唇侧的骨组织，直至留下一层透明骨覆盖牙周膜。将固定在牙齿上的血流仪探头发出的激光束透过变薄的骨组织。在切断的上牙槽神经远端进行电刺激后，观察到三种不同的血流反应模式：血流增加、血流减少和双相变化。将辣椒素应用于上牙槽神经可降低血流增加的反应，但对血流减少的反应无影响。另一方面，酚妥拉明预处理可完全抑制血流减少的反应，而血流增加的反应不受影响。目前的结果表明，猫牙周膜的血流受交感α-肾上腺素能纤维控制血管收缩，受感觉纤维控制血管舒张。
