Morimoto S, Imanaka S, Koh E, Shiraishi T, Nabata T, Kitano S, Miyashita Y, Nishii Y, Ogihara T
Department of Geriatric Medicine, Osaka University Medical School.
Biochem Int. 1989 Nov;19(5):1143-9.
The inhibitory effects of 1 alpha,25-(OH)2D3 and synthetic oxa-derivatives of vitamin D3 on growth of normal and psoriatic fibroblasts in culture were compared. Proliferation of normal fibroblasts was strongly inhibited by these new compounds in the following order: 22-oxa-1 alpha,25-(OH)2D3 greater than 22-oxa-1 alpha-(OH)D3 greater than 1 alpha,25-(OH)2D3 greater than 20-oxa-1 alpha,25-(OH)2D3. 22-Oxa-1 alpha,25-(OH)2D3 was about 10-times more inhibitory than 1 alpha,25-(OH)2D3. Proliferation of psoriatic fibroblasts was not inhibited by 1 alpha,25-(OH)2D3 at concentrations of up to 10(-6) M, but was suppressed by 10(-8)-10(-6) M 22-oxa-1 alpha,25-(OH)2D3 and 10(-6) M 22-oxa-1 alpha-(OH)D3. These results suggest that oxa-derivatives of vitamin D3, especially 22-oxa-1 alpha,25-(OH)2D3, should be useful in further studies on the cause and treatment of psoriasis.
比较了1α,25-(OH)₂D₃和维生素D₃的合成氧杂衍生物对培养的正常和银屑病成纤维细胞生长的抑制作用。这些新化合物对正常成纤维细胞增殖的抑制作用强弱顺序如下：22-氧杂-1α,25-(OH)₂D₃＞22-氧杂-1α-(OH)D₃＞1α,25-(OH)₂D₃＞20-氧杂-1α,25-(OH)₂D₃。22-氧杂-1α,25-(OH)₂D₃的抑制作用约为1α,25-(OH)₂D₃的10倍。在浓度高达10⁻⁶ M时，1α,25-(OH)₂D₃对银屑病成纤维细胞的增殖没有抑制作用，但10⁻⁸ - 10⁻⁶ M的22-氧杂-1α,25-(OH)₂D₃和10⁻⁶ M的22-氧杂-1α-(OH)D₃可抑制其增殖。这些结果表明，维生素D₃的氧杂衍生物，尤其是22-氧杂-1α,25-(OH)₂D₃，在银屑病病因及治疗的进一步研究中应具有应用价值。
