负责缓激肽在大鼠十二指肠中双相效应的受体的特性研究。

Characterization of the receptors responsible for the diphasic effect of bradykinin in rat duodenum.

作者信息

Pereira C C, Paiva T B

机构信息

Departamento de Biofísica, Escola Paulista de Medicina, São Paulo, Brasil.

出版信息

Braz J Med Biol Res. 1989;22(9):1137-40.

PMID:2561460

Abstract

The response of the rat duodenum to bradykinin (BK) consists of relaxant and contractile components, which have been attributed to different receptor types. To characterize the receptors responsible for this diphasic response we studied the effects of BK analogues known to act on B1 or B2 receptors in other systems. DesArg9-Leu8-BK and Thi5,8DPhe7-BK presented only relaxant and only contractile effects, respectively, whereas DArg0Hyp3Thi5,8DPhe7-BK was a potent antagonist of the relaxation (but not of the contraction) induced by BK. Our results show that the relaxant and contractile components of the rat duodenum's response to BK are due to B2 and B1 receptor subtypes, respectively.

摘要

大鼠十二指肠对缓激肽（BK）的反应包括舒张和收缩成分，这两种成分被认为分别归因于不同的受体类型。为了表征介导这种双相反应的受体，我们研究了已知在其他系统中作用于B1或B2受体的BK类似物的效应。去精氨酸9-亮氨酸8-缓激肽（DesArg9-Leu8-BK）和噻吩5,8-二苯丙氨酸7-缓激肽（Thi5,8DPhe7-BK）分别仅呈现舒张和收缩效应，而D-精氨酸0-羟脯氨酸3-噻吩5,8-二苯丙氨酸7-缓激肽（DArg0Hyp3Thi5,8DPhe7-BK）是BK诱导的舒张（而非收缩）的强效拮抗剂。我们的结果表明，大鼠十二指肠对BK反应的舒张和收缩成分分别归因于B2和B1受体亚型。