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胃癌放化疗后残留癌和基质细胞的分子特征：4例报告

Molecular characteristics of residual cancer and stromal cells after chemoradiotherapy for gastric cancer: report of four cases.

作者信息

Tanaka Koji, Mohri Yasuhiko, Koike Yuhki, Okugawa Yoshinaga, Toiyama Yuji, Ohi Masaki, Kobayashi Minako, Inoue Yasuhiro, Araki Toshimitsu, Uchida Keiichi, Miki Chikao, Kusunoki Masato

机构信息

Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

出版信息

Clin Case Rep. 2014 Oct;2(5):165-72. doi: 10.1002/ccr3.68. Epub 2014 Jun 4.

DOI:10.1002/ccr3.68
PMID:25614804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4302618/
Abstract

Four patients with gastric cancer underwent 5-fluorouracil and cisplatin-based chemoradiotherapy followed by surgery. Expression analysis of chemoradiosensitivity related genes in residual cancer using formalin-fixed paraffin-embedded specimens may be useful when determining a chemotherapy regimen for disease recurrence after chemoradiotherapy for gastric cancer.

摘要

4例胃癌患者接受了以5-氟尿嘧啶和顺铂为基础的放化疗，随后接受手术。在确定胃癌放化疗后疾病复发的化疗方案时，使用福尔马林固定石蜡包埋标本对残留癌中放化疗敏感性相关基因进行表达分析可能会有所帮助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba5/4302618/c8e3df94daf4/ccr30002-0165-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba5/4302618/c5ae6e5582b1/ccr30002-0165-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba5/4302618/a4511acbf9e9/ccr30002-0165-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba5/4302618/a6db54e9392d/ccr30002-0165-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba5/4302618/c8e3df94daf4/ccr30002-0165-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba5/4302618/c5ae6e5582b1/ccr30002-0165-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba5/4302618/a4511acbf9e9/ccr30002-0165-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba5/4302618/a6db54e9392d/ccr30002-0165-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba5/4302618/c8e3df94daf4/ccr30002-0165-f4.jpg

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本文引用的文献

1
Expression profiling of stem cell-related genes in neoadjuvant-treated gastric cancer: a NOTCH2, GSK3B and β-catenin gene signature predicts survival.在新辅助治疗的胃癌中干细胞相关基因的表达谱分析：NOTCH2、GSK3B 和 β-连环蛋白基因特征可预测生存。
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Excision-repair cross-complementing 1 predicts response to cisplatin-based neoadjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma.切除修复交叉互补基因1可预测食管鳞状细胞癌患者对顺铂新辅助放化疗的反应。
Mol Med Rep. 2009 Nov-Dec;2(6):903-9. doi: 10.3892/mmr_00000190.
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COX2 expression predicts resistance to chemoradiotherapy in esophageal squamous cell carcinoma.
COX2 表达预测食管鳞癌对放化疗的耐药性。
Ann Surg Oncol. 2011 Oct;18(10):2946-51. doi: 10.1245/s10434-011-1645-z. Epub 2011 Mar 25.
4
A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer.一种与基质相关的基因特征可预测乳腺癌对新辅助化疗的耐药性。
Nat Med. 2009 Jan;15(1):68-74. doi: 10.1038/nm.1908. Epub 2009 Jan 4.
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The epidermal growth factor receptor: a role in repair of radiation-induced DNA damage.表皮生长因子受体：在辐射诱导的DNA损伤修复中的作用。
Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6555-60. doi: 10.1158/1078-0432.CCR-07-1610.
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Impact of vascular endothelial growth factor release on radiation resistance.血管内皮生长因子释放对辐射抗性的影响。
Oncol Rep. 2007 Dec;18(6):1597-601.
7
Clinical parameters predicting pathologic tumor response after preoperative chemoradiotherapy for rectal cancer.预测直肠癌术前放化疗后病理肿瘤反应的临床参数。
Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1167-72. doi: 10.1016/j.ijrobp.2007.04.047.
8
For localized gastroesophageal cancer, you give chemoradiation before surgery, but then what happens?对于局部性的胃食管癌，术前要进行放化疗，但之后会怎样呢？
J Clin Oncol. 2007 Sep 20;25(27):4315-6. doi: 10.1200/JCO.2007.11.8026.
9
Clinical stage after preoperative chemoradiation is a better predictor of patient outcome than the baseline stage for localized gastric cancer.对于局部胃癌患者，术前放化疗后的临床分期比基线期更能预测患者的预后。
Cancer. 2007 Sep 1;110(5):989-95. doi: 10.1002/cncr.22870.
10
Influence of tumor cell and stroma sensitivity on tumor response to radiation.肿瘤细胞和基质敏感性对肿瘤放疗反应的影响。
Cancer Res. 2007 May 1;67(9):4016-21. doi: 10.1158/0008-5472.CAN-06-4498.