Kim Rebecca, Kim Yu Cheol
Department of Ophthalmology, Keimyung University School of Medicine, Dongsan Medical Center, 56 Dalseong-ro, Jung-gu, Daegu 700-712, Republic of Korea.
J Ophthalmol. 2014;2014:257286. doi: 10.1155/2014/257286. Epub 2014 Dec 28.
Purpose. To report the results of the posterior pole sparing laser photocoagulation combined with intravitreal bevacizumab injection (IVB) in retinopathy of prematurity (ROP). Methods. A retrospective chart review of premature babies with ROP, all of whom received laser photocoagulation with IVB. Eleven eyes of 6 infants with advanced zone I ROP underwent laser ablation sparing posterior pole with concurrent IVB. The results were compared with those of full-laser treatment combined with IVB to 8 eyes of 5 infants with advanced ROP without involvement of the posterior pole. Results. The posterior pole sparing laser with IVB was performed with zone I, stage 3+ ROP at the mean postmenstrual age of 36 weeks and 5 days. The plus sign decreased significantly at postoperative day 1, the neovascular proliferation regressed by postoperative week 1, and the normal vascularization started at postoperative day 32 on the average. Two months after treatment, vascularization of the spared avascular area was completed. There was no macular dragging, tractional retinal detachment, foveal destruction by laser scars, or any other adverse event. No significant anatomical differences were identified from those of full-laser ablation combined with IVB. Conclusions. Posterior pole sparing laser with IVB can give favorable results without destruction of posterior pole retina.
目的。报告后极部保留激光光凝联合玻璃体内注射贝伐单抗（IVB）治疗早产儿视网膜病变（ROP）的结果。方法。对患有ROP的早产儿进行回顾性病历审查，所有患儿均接受了激光光凝联合IVB治疗。6例患有I区晚期ROP的婴儿的11只眼接受了保留后极部的激光消融并同时注射IVB。将结果与5例患有晚期ROP且后极部未受累的婴儿的8只眼接受全激光治疗联合IVB的结果进行比较。结果。保留后极部激光联合IVB治疗在平均孕龄36周零5天时用于I区3+期ROP。术后第1天加号征明显减轻，术后第1周新生血管增殖消退，平均术后第32天开始正常血管化。治疗后两个月，保留的无血管区血管化完成。没有黄斑牵拉、牵引性视网膜脱离、激光瘢痕导致的黄斑破坏或任何其他不良事件。与全激光消融联合IVB相比，未发现明显的解剖学差异。结论。保留后极部激光联合IVB可取得良好效果，且不破坏后极部视网膜。
