[Treatment of depression: the current state and perspectives of the development of pharmacological studies].

A review of literature over the last two decades is presented. It is emphasized that psyachopharmacotherapy currently remains a main method of treatment of severe and moderate depression. Pharmacogenetic studies are directed mainly towards the identification of probable targets based on pharmacokinetcs and pharmacodynamics of andidepressants as well as the aspect of identification of probably predictors for treatment response.