中国北方地区3型和7型腺病毒致婴幼儿肺炎的分子流行病学研究

A study of molecular epidemiology of adenovirus of types 3 and 7 on infant pneumonia in northern China.

作者信息

Fu W Y, Liang D, Zheng Y C, Liu W M, Xu Z, Guo H J, Wang Z L

出版信息

Chin Med J (Engl). 1989 Nov;102(11):857-61.

Abstract

This paper analysed 102 strains of adenovirus types 3(Ad3) and 7(Ad7) causing infant pneumonia from 1976 to 1988 in northern China. Two genotypes of Ad7, 7b and 7d, were identified by using restriction endonucleases, BamHI, BcLI, BgLI, SmaI, XbaI and HindIII. 3 genotypes of Ad3, 3I, 3II and 3III, were identified by using BgLII and BamHI. Of 56 Ad7 strains, 34 were 7b (76.8%) spread over last 10 years; 13 7d(23.2%) occurred from 1982, together with 7b. Of 46 Ad3 strains, 42 3I(91.3%) spread over the past 12 years. 3II and 3III scattered all over these years. Ad3I and Ad7b were the dominant genotypes. The results indicated that Ad7d tended to increase with time from 1982. It is possible that Ad7d will become dominant genotype and replace Ad7b.

摘要

本文分析了1976年至1988年中国北方地区引起婴幼儿肺炎的102株3型（Ad3）和7型（Ad7）腺病毒。使用限制性内切酶BamHI、BcLI、BgLI、SmaI、XbaI和HindIII鉴定出Ad7的两种基因型，即7b和7d。使用BgLII和BamHI鉴定出Ad3的三种基因型，即3I、3II和3III。在56株Ad7菌株中，34株为7b型（76.8%），分布在过去10年；13株为7d型（23.2%），于1982年出现，与7b型同时存在。在46株Ad3菌株中，42株为3I型（91.3%），分布在过去12年。3II型和3III型这些年零星分布。Ad3I和Ad7b是主要基因型。结果表明，自1982年起Ad7d有随时间增加的趋势。Ad7d有可能成为优势基因型并取代Ad7b。