RIP140通过抑制ABCA1/G1表达以及经由肝脏X受体的胆固醇流出，触发泡沫细胞形成。
RIP140 triggers foam-cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor.
作者信息
He Yanhong, Zhang Luankun, Li Zhuoming, Gao Hui, Yue Zhongbao, Liu Zhiping, Liu Xueping, Feng Xiaojun, Liu Peiqing
机构信息
Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
Department of Pharmacy, Sun Yat-sen University cancer center, Guangzhou 510060, PR China.
出版信息
FEBS Lett. 2015 Feb 13;589(4):455-60. doi: 10.1016/j.febslet.2015.01.001. Epub 2015 Jan 20.
Receptor-interacting protein 140 (RIP140) is a multifunctional coregulator of lipid metabolism and inflammation. However, the potential role of RIP140 in atherosclerosis remains unknown. The present study investigated the impact of RIP140 on foam cell formation, a critical step in pathogenesis of atherosclerosis. The expression of RIP140 was increased in foam cells. RIP140 overexpression resulted in decreased cholesterol efflux in macrophages and their concomitant differentiation into foam cells. Moreover, RIP140 negatively regulated the macrophage expression of ATP-binding cassette transporters A1 and G1 (ABCA1/G1), by suppressing the expression and activity of liver X receptor (LXR). These findings shed light onto the contribution of RIP140 to the development and progression of atherosclerosis, and suggest a novel therapeutic target for the treatment of atherosclerosis.
受体相互作用蛋白140（RIP140）是脂质代谢和炎症的多功能共调节因子。然而，RIP140在动脉粥样硬化中的潜在作用尚不清楚。本研究调查了RIP140对泡沫细胞形成的影响，泡沫细胞形成是动脉粥样硬化发病机制中的关键步骤。RIP140在泡沫细胞中的表达增加。RIP140的过表达导致巨噬细胞中胆固醇流出减少，并使其伴随分化为泡沫细胞。此外，RIP140通过抑制肝X受体（LXR）的表达和活性，负向调节巨噬细胞中ATP结合盒转运蛋白A1和G1（ABCA1/G1）的表达。这些发现揭示了RIP140对动脉粥样硬化发生发展的作用，并提示了一种治疗动脉粥样硬化的新靶点。
Zotero 插件