Evidence for idiotype-directed immunosurveillance is restricted to follicular lymphoma and attributable to somatic hypermutation.
作者信息
Papaioannou Dimitrios, Strothmeyer Anna-Maria, Dühren-von Minden Marcus, Keppler-Hafkemeyer Andrea, Zirlik Katja, Mikesch Kristina, van Bergen Cornelis A M, Navarrete Marcelo A, Veelken Hendrik
机构信息
Department of Hematology/Oncology, University Medical Center Freiburg, Germany.
Department of Hematology, Leiden University Medical Center, The Netherlands.
出版信息
Haematologica. 2015 Apr;100(4):e143-6. doi: 10.3324/haematol.2014.111252. Epub 2015 Jan 23.
Abstract
摘要
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Evidence for idiotype-directed immunosurveillance is restricted to follicular lymphoma and attributable to somatic hypermutation.独特型导向免疫监视的证据仅限于滤泡性淋巴瘤，且归因于体细胞超突变。
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本文引用的文献
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Upfront immunization with autologous recombinant idiotype Fab fragment without prior cytoreduction in indolent B-cell lymphoma.惰性 B 细胞淋巴瘤中，在进行细胞减灭前使用自体重组独特型 Fab 片段进行 upfront 免疫接种。
Blood. 2011 Feb 3;117(5):1483-91. doi: 10.1182/blood-2010-06-292342. Epub 2010 Nov 2.
2
Comparative analysis of predicted HLA binding of immunoglobulin idiotype sequences indicates T cell-mediated immunosurveillance in follicular lymphoma.免疫球蛋白独特型序列预测 HLA 结合的比较分析表明滤泡性淋巴瘤中 T 细胞介导的免疫监视。
Blood. 2010 Sep 9;116(10):1734-6. doi: 10.1182/blood-2010-02-270199. Epub 2010 Jun 3.
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Review: to what extent are T cells tolerant to immunoglobulin variable regions?综述：T细胞对免疫球蛋白可变区的耐受程度如何？
Scand J Immunol. 2009 Dec;70(6):526-30. doi: 10.1111/j.1365-3083.2009.02340.x.
4
Cloning of idiotype immunoglobulin genes in B cell lymphomas by anchored PCR and production of individual recombinant idiotype vaccines in Escherichia coli.通过锚定PCR克隆B细胞淋巴瘤中的独特型免疫球蛋白基因并在大肠杆菌中生产个体重组独特型疫苗。
Eur J Haematol. 2006 Nov;77(5):395-402. doi: 10.1111/j.1600-0609.2006.00740.x. Epub 2006 Jul 27.
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Phase I trial of a novel intradermal idiotype vaccine in patients with advanced B-cell lymphoma: specific immune responses despite profound immunosuppression.新型皮内独特型疫苗用于晚期B细胞淋巴瘤患者的I期试验：尽管存在严重免疫抑制仍有特异性免疫反应。
Cancer Res. 2006 Apr 15;66(8):4496-502. doi: 10.1158/0008-5472.CAN-05-4233.
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Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells.基于肿瘤浸润免疫细胞分子特征预测滤泡性淋巴瘤的生存率
N Engl J Med. 2004 Nov 18;351(21):2159-69. doi: 10.1056/NEJMoa041869.
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Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas.活化诱导胞苷脱氨酶在人B细胞非霍奇金淋巴瘤中的表达
Blood. 2003 May 1;101(9):3574-80. doi: 10.1182/blood-2002-08-2424. Epub 2003 Jan 2.
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Nat Med. 2000 Jun;6(6):667-72. doi: 10.1038/76243.
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