Ferrandino Ida, Monaco Antonio, Grimaldi Maria Consiglio
Department of Biology, University of Naples Federico II, Via Mezzocannone 8, 80134 Napoli, Italy.
Department of Biology, University of Naples Federico II, Via Mezzocannone 8, 80134 Napoli, Italy.
C R Biol. 2015 Mar;338(3):180-4. doi: 10.1016/j.crvi.2014.12.006. Epub 2015 Jan 20.
Leptin is the hormone synthesised by adipocytes, which plays an important role in regulating appetite and metabolism. In mammals, this pleiotropic hormone also plays a key role in controlling gonadotropin secretion by stimulatory hypothalamic and pituitary actions. However, little is known about leptin in lower vertebrates and particularly few studies are available on reptiles. In the present work, we analysed the action of recombinant human leptin on FSH cells in the pituitary gland of Podarcis siculus female lizards exposed to four different concentrations of the hormone. FSH cells showed a dose-dependent reaction. The data are indicative of the role played by leptin in modulating the cellular activity of such cells in the pituitary gland of P. siculus, similar to what was already reported in mammals. A functional receptor is evidently able to respond to leptin in this lizard, but further comparative studies are needed to understand the role of this hormone in ectothermic vertebrates.
瘦素是由脂肪细胞合成的激素，在调节食欲和新陈代谢中起重要作用。在哺乳动物中，这种多效性激素还通过刺激下丘脑和垂体的作用，在控制促性腺激素分泌方面发挥关键作用。然而，关于低等脊椎动物中的瘦素所知甚少，特别是关于爬行动物的研究很少。在本研究中，我们分析了重组人瘦素对暴露于四种不同浓度该激素的意大利壁蜥雌性蜥蜴垂体中促卵泡激素（FSH）细胞的作用。FSH细胞呈现出剂量依赖性反应。这些数据表明瘦素在调节意大利壁蜥垂体中此类细胞的细胞活性方面所起的作用，这与哺乳动物中已报道的情况类似。显然，功能性受体能够对这种蜥蜴体内的瘦素作出反应，但需要进一步的比较研究来了解这种激素在变温脊椎动物中的作用。
