Bernal Antonio, Mahía Javier, Mediavilla Cristina, Puerto Amadeo
Department of Psychobiology and Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada 18071, Spain.
Department of Psychobiology and Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada 18071, Spain.
Physiol Behav. 2015 Mar 15;141:135-42. doi: 10.1016/j.physbeh.2015.01.022. Epub 2015 Jan 21.
Oxytocin (OT), a neurohormone, has been related to natriuretic and diuretic effects and also to water intake and sodium appetite. The objective of the present study was to determine the effect of subcutaneous OT administration on water intake and urine-related measures induced by the administration of hypertonic NaCl (experiment 1) or polyethylene glycol (PEG) (experiment 2). Experiment 1 showed that OT administration increases the urine volume, urinary sodium concentration, and natriuresis and reduces the water intake, water and sodium balances, and estimated plasma sodium concentration induced by hypertonic NaCl administration. Conversely, experiment 2 showed that OT administration increases the water intake and the antidiuretic response induced by PEG administration. These results show that the opposite effects of OT on the water intake induced by hypertonic NaCl or PEG administration are accompanied by differential regulatory effects, enhancing a natriuretic response in the first experiment and generating an antidiuretic reaction in the second experiment. This study suggests a differential regulatory effect of OT during states of intra- and extracellular thirst.
催产素（OT）是一种神经激素，与利钠和利尿作用以及水摄入和钠食欲有关。本研究的目的是确定皮下注射OT对高渗氯化钠（实验1）或聚乙二醇（PEG）（实验2）给药诱导的水摄入和尿液相关指标的影响。实验1表明，注射OT可增加尿量、尿钠浓度和尿钠排泄，并减少高渗氯化钠给药诱导的水摄入、水和钠平衡以及估计的血浆钠浓度。相反，实验2表明，注射OT可增加PEG给药诱导的水摄入和抗利尿反应。这些结果表明，OT对高渗氯化钠或PEG给药诱导的水摄入的相反作用伴随着不同的调节作用，在第一个实验中增强了利钠反应，在第二个实验中产生了抗利尿反应。本研究提示OT在细胞内和细胞外口渴状态下具有不同的调节作用。
