Tuna Mazhar Müslüm, Doğan Berçem Ayçiçek, Karakılıç Ersen, Arduç Ayşe, Işık Serhat, Yılmaz Fatma Meriç, Topçuoğlu Canan, Berker Dilek, Güler Serdar
Department of Endocrinology and Metabolism, Medical Faculty, Dicle University, Turkey.
Department of Endocrinology and Metabolism, Ankara Numune Training and Research Hospital, Turkey.
Neuro Endocrinol Lett. 2014;35(7):640-4.
Hypogonadism has major effects on the urogenital system, in addition to other systems, the cardiovascular system in particular. There have been few studies conducted on markers of atherosclerosis, such as flow mediated dilatation (% FMD), carotid intima-media thickness (CIMT) and adipocytokine levels in idiopatic hypogonadotropic hypogonadal (IHH) males mostly in adult patients. The aim of this study was to evaluate the relationship between androgens and adipocytokines and parameters of vascular functions in hypogonadal men.
The study population consisted of 11 treatment naive IHH patients (group 1) and 15 age-matched healthy control males (group 2). A fasting blood sample was obtained for leptin, adiponectin and resistin. The endothelial functions were evaluated by studying % FMD and CIMT by high resolution B-mode ultrasound.
No significant differences in age, body mass index, systolic and diastolic blood pressure were recorded between the two groups. The leptin level was significantly higher in group 1, whereas adiponectin and resistin levels were same between two groups. There was a negative correlation between total testosterone and carotid intima-media thickness (r=-0.656, p=0.008), and a negative correlation between total testosterone and leptin level (r=-0.794, p<0.001). No correlation was found between leptin and CIMT (p=0.184).
Testosterone deficiency in hypogonadal men is associated with vascular parameters of atherosclerosis. The findings may establish indications for testosterone replacement therapy in hypogonadal men.
性腺功能减退除了对泌尿生殖系统有重大影响外，还会影响其他系统，尤其是心血管系统。关于动脉粥样硬化标志物的研究较少，如血流介导的血管舒张（%FMD）、颈动脉内膜中层厚度（CIMT）以及特发性低促性腺激素性性腺功能减退（IHH）男性（大多为成年患者）的脂肪细胞因子水平。本研究的目的是评估性腺功能减退男性体内雄激素、脂肪细胞因子与血管功能参数之间的关系。
研究人群包括11例未经治疗的IHH患者（第1组）和15例年龄匹配的健康对照男性（第2组）。采集空腹血样检测瘦素、脂联素和抵抗素。通过高分辨率B型超声研究%FMD和CIMT来评估内皮功能。
两组在年龄、体重指数、收缩压和舒张压方面无显著差异。第1组的瘦素水平显著更高，而两组之间的脂联素和抵抗素水平相同。总睾酮与颈动脉内膜中层厚度呈负相关（r = -0.656，p = 0.008），总睾酮与瘦素水平呈负相关（r = -0.794，p < 0.001）。瘦素与CIMT之间未发现相关性（p = 0.184）。
性腺功能减退男性的睾酮缺乏与动脉粥样硬化的血管参数相关。这些发现可能为性腺功能减退男性的睾酮替代治疗提供依据。
