重度大麻使用者吸烟后δ-1-四氢大麻酚-7-酸的尿排泄半衰期。
Urinary elimination half-life of delta-1-tetrahydrocannabinol-7-oic acid in heavy marijuana users after smoking.
作者信息
Johansson E K, Hollister L E, Halldin M M
机构信息
Department of Pharmacognosy, BMC, Uppsala, Sweden.
出版信息
NIDA Res Monogr. 1989;95:457-8.
The urinary excretion of delta 1-tetrahydrocannabinol-7-oic acid (delta 1-THC-7-oic acid), the major urinary metabolite of delta 1-THC, and the total amount of THC metabolites was studied in heavy marijuana users after smoking using high-performance liquid chromatography and the EMT-d.a.u. cannabinoid assay. An average elimination half-life (+/- SD) of 3.0 +/- 2.3 days was obtained for delta 1-THC-7-oic acid. The average ratio (+/- SD) of "EMIT readings"/delta 1-THC-7-oic acid concentrations was 1.23 +/- 1.03.
使用高效液相色谱法和EMT-d.a.u.大麻素分析方法，对重度大麻使用者吸食大麻后尿液中主要代谢物δ1-四氢大麻酚-7-酸（δ1-THC-7-酸）以及THC代谢物总量进行了研究。δ1-THC-7-酸的平均消除半衰期（±标准差）为3.0±2.3天。“EMIT读数”与δ1-THC-7-酸浓度的平均比值（±标准差）为1.23±1.03。
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