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Synthesis, resolution, and determination of absolute configuration of protected α-ethynylphenylalanine enantiomers.

作者信息

Benfodda Z, Bénimélis D, Jean M, Naubron J-V, Rolland V, Meffre P

机构信息

UNIV. NIMES, EA7352 CHROME, Rue du Dr G. Salan, 30021, Nîmes Cedex 1, France,

出版信息

Amino Acids. 2015 May;47(5):899-907. doi: 10.1007/s00726-015-1917-1. Epub 2015 Jan 25.

DOI:10.1007/s00726-015-1917-1
PMID:25618753
Abstract

Racemic-protected α-ethynylphenylalanine was synthesized from DL-2-benzylserine using α-benzylserinal as key intermediate and was successfully resolved by HPLC on a chiral stationary phase at a semipreparative scale. The absolute configuration of both enantiomers was determined by vibrational circular dichroism.

摘要

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